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7 Dec 2025

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Comprehensive AS Level Biology Notes: Prokaryotic and Eukaryotic Cells

user profile picture

Bethan Jones @bethanjones_jdhy

Understanding cell structure is absolutely crucial for your A-level Biology success - from prokaryotes to complex eukaryotes, these... Show more

Prokaryotic cell
DNA-
mesosome.
(site of aerob
respiration)
70s
ribosome
Protein
Coat
-Slime Coat on some
bacteria
wall
-cell
-cell membrane

Prokaryotic Cells and Viruses

Prokaryotic cells are the simplest cellular structures you'll encounter, found in bacteria and blue-green algae. Unlike the cells in your body, they don't have a membrane-bound nucleus - instead, their DNA floats freely in the cytoplasm within a region called the nucleoid.

These cells are surprisingly efficient with their basic setup. They've got 70S ribosomes for protein synthesis, and their cell walls are made from peptidoglycan (also called murein), not cellulose like plants. The mesosome - formed by the cell membrane folding inwards - serves as the site for aerobic respiration.

Viruses are even simpler and technically aren't even alive. They're incredibly tiny (electron microscope required!) and consist of just a protein coat surrounding DNA or RNA. Some have spikes for attaching to specific cells, and bacteriophages are viruses that specifically target bacteria.

Key Point Remember that prokaryotic cells are complete living organisms, whilst viruses need to hijack other cells to reproduce!

Prokaryotic cell
DNA-
mesosome.
(site of aerob
respiration)
70s
ribosome
Protein
Coat
-Slime Coat on some
bacteria
wall
-cell
-cell membrane

Eukaryotic Cell Structure

Eukaryotic cells are the sophisticated type found in plants, animals, and fungi - they're packed with membrane-bound organelles that prokaryotes lack. Think of organelles as specialized departments in a factory, each with specific jobs that keep the cell running smoothly.

The nucleus is your cell's command centre, housing DNA and controlling protein synthesis. It's surrounded by a double membrane with pores that allow mRNA to exit. Inside, you'll find the nucleolus, which produces ribosomes and rRNA.

Mitochondria are the cell's powerhouses, producing ATP through aerobic respiration. Their inner membrane folds into cristae, creating massive surface areas for enzyme attachment. Metabolically active cells like muscle and liver cells are packed with these energy factories.

Exam Tip When describing organelles, always mention their membrane structure and specific function - examiners love these details!

Prokaryotic cell
DNA-
mesosome.
(site of aerob
respiration)
70s
ribosome
Protein
Coat
-Slime Coat on some
bacteria
wall
-cell
-cell membrane

Protein Synthesis and Transport Systems

The endoplasmic reticulum (ER) is your cell's highway system, transporting molecules throughout the cytoplasm. Rough ER has ribosomes attached, specialising in protein transport, whilst smooth ER handles lipid synthesis and transport.

Ribosomes are protein-making machines found freely in the cytoplasm or attached to rough ER. Eukaryotic cells use 80S ribosomes, whilst prokaryotes stick with 70S versions. They're made from RNA and protein, with specific sites for mRNA and tRNA attachment.

The Golgi body acts like a post office, modifying and packaging proteins received from the rough ER. It's brilliant at producing enzymes, forming lysosomes, and creating glycoproteins. Everything gets transported in vesicles that bud off from its surfaces.

Memory Trick Think "Rough ER = Ribosomes = pRotein transport" - the alliteration helps you remember!

Prokaryotic cell
DNA-
mesosome.
(site of aerob
respiration)
70s
ribosome
Protein
Coat
-Slime Coat on some
bacteria
wall
-cell
-cell membrane

Specialized Organelles

Lysosomes are the cell's recycling centres, found mainly in animal cells. These vesicles contain digestive enzymes that break down worn-out organelles and cellular waste. They're formed by budding off from the Golgi body.

Centrioles are crucial for cell division, found in animal cells near the nucleus. These hollow cylinders work in pairs, moving to opposite poles during division to help pull chromosomes apart via spindle fibres.

Chloroplasts are plant cell specialists conducting photosynthesis. They capture sunlight energy, convert it to ATP, and release oxygen from water. Like mitochondria, they contain their own DNA and 70S ribosomes, making them self-replicating.

Vacuoles serve different purposes - small ones in animal cells for storage, but massive ones in plant cells that provide structural support and maintain turgor pressure.

Plant vs Animal Remember that chloroplasts and large vacuoles are plant-exclusive, whilst centrioles are typically animal-only!

Prokaryotic cell
DNA-
mesosome.
(site of aerob
respiration)
70s
ribosome
Protein
Coat
-Slime Coat on some
bacteria
wall
-cell
-cell membrane

Cell Walls and Levels of Organisation

Plant cell walls are made from cellulose betaglucosechainsbeta-glucose chains and provide structural strength whilst resisting vacuole expansion. Plasmodesmata are microscopic channels connecting plant cells, allowing communication and transport between them.

The key differences between cell types are straightforward. Prokaryotes (bacteria) have no membrane-bound organelles and 70S ribosomes, with cell walls made of murein. Eukaryotes (plants, animals, fungi) have membrane-bound organelles and 80S ribosomes.

Levels of organisation follow a logical hierarchy in multicellular organisms. Similar cells group into tissues (like muscle tissue), different tissues combine into organs (like your heart), organs work together as systems (like your circulatory system), and systems combine to form complete organisms.

Exam Focus Understanding this hierarchy is essential for questions about how structure relates to function at different biological levels!

Prokaryotic cell
DNA-
mesosome.
(site of aerob
respiration)
70s
ribosome
Protein
Coat
-Slime Coat on some
bacteria
wall
-cell
-cell membrane

Tissue Types and Functions

Epithelial tissue forms protective barriers, covering internal and external body surfaces. It lacks blood vessels but contains nerve endings, with cells sitting on a basement membrane made of collagen and proteins.

Cuboidal epithelial tissue appears in kidney tubules and ovary surfaces, providing protection from abrasion and water loss. Ciliated epithelial tissue lines your respiratory tract, with hair-like cilia that wave to move mucus upwards - essential for keeping your lungs clean.

Muscle tissue comes in two main types. Smooth muscle found in blood vessels and intestines allows fine control without conscious effort. Striated (skeletal) muscle attaches to bones for voluntary movement and shows distinctive striped patterns under a microscope.

Real-World Connection Every time you cough to clear mucus, you're relying on ciliated epithelial tissue doing its job perfectly!

Prokaryotic cell
DNA-
mesosome.
(site of aerob
respiration)
70s
ribosome
Protein
Coat
-Slime Coat on some
bacteria
wall
-cell
-cell membrane

Connective Tissue

Connective tissue is your body's structural framework, found in tendons, ligaments, and cartilage. It fills spaces between organs and tissues whilst providing essential structural support throughout your body.

This tissue type is incredibly versatile, adapting to provide exactly the right amount of support where needed. Whether it's the tough tendons connecting muscle to bone or the flexible cartilage cushioning your joints, connective tissue keeps everything properly positioned and functioning.

Remember Connective tissue literally connects and supports - the name tells you exactly what it does!

We thought you’d never ask...

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Where can I download the Knowunity app?

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Anna

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Best app on earth! no words because it’s too good

Thomas R

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Paul T

iOS user

 

Biology

253

7 Dec 2025

7 pages

Comprehensive AS Level Biology Notes: Prokaryotic and Eukaryotic Cells

user profile picture

Bethan Jones

@bethanjones_jdhy

Understanding cell structure is absolutely crucial for your A-level Biology success - from prokaryotes to complex eukaryotes, these microscopic building blocks determine how all life functions. We'll explore everything from bacterial simplicity to the intricate organelles that power plant and... Show more

Prokaryotic cell
DNA-
mesosome.
(site of aerob
respiration)
70s
ribosome
Protein
Coat
-Slime Coat on some
bacteria
wall
-cell
-cell membrane

Sign up to see the contentIt's free!

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Prokaryotic Cells and Viruses

Prokaryotic cells are the simplest cellular structures you'll encounter, found in bacteria and blue-green algae. Unlike the cells in your body, they don't have a membrane-bound nucleus - instead, their DNA floats freely in the cytoplasm within a region called the nucleoid.

These cells are surprisingly efficient with their basic setup. They've got 70S ribosomes for protein synthesis, and their cell walls are made from peptidoglycan (also called murein), not cellulose like plants. The mesosome - formed by the cell membrane folding inwards - serves as the site for aerobic respiration.

Viruses are even simpler and technically aren't even alive. They're incredibly tiny (electron microscope required!) and consist of just a protein coat surrounding DNA or RNA. Some have spikes for attaching to specific cells, and bacteriophages are viruses that specifically target bacteria.

Key Point: Remember that prokaryotic cells are complete living organisms, whilst viruses need to hijack other cells to reproduce!

Prokaryotic cell
DNA-
mesosome.
(site of aerob
respiration)
70s
ribosome
Protein
Coat
-Slime Coat on some
bacteria
wall
-cell
-cell membrane

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Eukaryotic Cell Structure

Eukaryotic cells are the sophisticated type found in plants, animals, and fungi - they're packed with membrane-bound organelles that prokaryotes lack. Think of organelles as specialized departments in a factory, each with specific jobs that keep the cell running smoothly.

The nucleus is your cell's command centre, housing DNA and controlling protein synthesis. It's surrounded by a double membrane with pores that allow mRNA to exit. Inside, you'll find the nucleolus, which produces ribosomes and rRNA.

Mitochondria are the cell's powerhouses, producing ATP through aerobic respiration. Their inner membrane folds into cristae, creating massive surface areas for enzyme attachment. Metabolically active cells like muscle and liver cells are packed with these energy factories.

Exam Tip: When describing organelles, always mention their membrane structure and specific function - examiners love these details!

Prokaryotic cell
DNA-
mesosome.
(site of aerob
respiration)
70s
ribosome
Protein
Coat
-Slime Coat on some
bacteria
wall
-cell
-cell membrane

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Protein Synthesis and Transport Systems

The endoplasmic reticulum (ER) is your cell's highway system, transporting molecules throughout the cytoplasm. Rough ER has ribosomes attached, specialising in protein transport, whilst smooth ER handles lipid synthesis and transport.

Ribosomes are protein-making machines found freely in the cytoplasm or attached to rough ER. Eukaryotic cells use 80S ribosomes, whilst prokaryotes stick with 70S versions. They're made from RNA and protein, with specific sites for mRNA and tRNA attachment.

The Golgi body acts like a post office, modifying and packaging proteins received from the rough ER. It's brilliant at producing enzymes, forming lysosomes, and creating glycoproteins. Everything gets transported in vesicles that bud off from its surfaces.

Memory Trick: Think "Rough ER = Ribosomes = pRotein transport" - the alliteration helps you remember!

Prokaryotic cell
DNA-
mesosome.
(site of aerob
respiration)
70s
ribosome
Protein
Coat
-Slime Coat on some
bacteria
wall
-cell
-cell membrane

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By signing up you accept Terms of Service and Privacy Policy

Specialized Organelles

Lysosomes are the cell's recycling centres, found mainly in animal cells. These vesicles contain digestive enzymes that break down worn-out organelles and cellular waste. They're formed by budding off from the Golgi body.

Centrioles are crucial for cell division, found in animal cells near the nucleus. These hollow cylinders work in pairs, moving to opposite poles during division to help pull chromosomes apart via spindle fibres.

Chloroplasts are plant cell specialists conducting photosynthesis. They capture sunlight energy, convert it to ATP, and release oxygen from water. Like mitochondria, they contain their own DNA and 70S ribosomes, making them self-replicating.

Vacuoles serve different purposes - small ones in animal cells for storage, but massive ones in plant cells that provide structural support and maintain turgor pressure.

Plant vs Animal: Remember that chloroplasts and large vacuoles are plant-exclusive, whilst centrioles are typically animal-only!

Prokaryotic cell
DNA-
mesosome.
(site of aerob
respiration)
70s
ribosome
Protein
Coat
-Slime Coat on some
bacteria
wall
-cell
-cell membrane

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Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Cell Walls and Levels of Organisation

Plant cell walls are made from cellulose betaglucosechainsbeta-glucose chains and provide structural strength whilst resisting vacuole expansion. Plasmodesmata are microscopic channels connecting plant cells, allowing communication and transport between them.

The key differences between cell types are straightforward. Prokaryotes (bacteria) have no membrane-bound organelles and 70S ribosomes, with cell walls made of murein. Eukaryotes (plants, animals, fungi) have membrane-bound organelles and 80S ribosomes.

Levels of organisation follow a logical hierarchy in multicellular organisms. Similar cells group into tissues (like muscle tissue), different tissues combine into organs (like your heart), organs work together as systems (like your circulatory system), and systems combine to form complete organisms.

Exam Focus: Understanding this hierarchy is essential for questions about how structure relates to function at different biological levels!

Prokaryotic cell
DNA-
mesosome.
(site of aerob
respiration)
70s
ribosome
Protein
Coat
-Slime Coat on some
bacteria
wall
-cell
-cell membrane

Sign up to see the contentIt's free!

Access to all documents

Improve your grades

Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Tissue Types and Functions

Epithelial tissue forms protective barriers, covering internal and external body surfaces. It lacks blood vessels but contains nerve endings, with cells sitting on a basement membrane made of collagen and proteins.

Cuboidal epithelial tissue appears in kidney tubules and ovary surfaces, providing protection from abrasion and water loss. Ciliated epithelial tissue lines your respiratory tract, with hair-like cilia that wave to move mucus upwards - essential for keeping your lungs clean.

Muscle tissue comes in two main types. Smooth muscle found in blood vessels and intestines allows fine control without conscious effort. Striated (skeletal) muscle attaches to bones for voluntary movement and shows distinctive striped patterns under a microscope.

Real-World Connection: Every time you cough to clear mucus, you're relying on ciliated epithelial tissue doing its job perfectly!

Prokaryotic cell
DNA-
mesosome.
(site of aerob
respiration)
70s
ribosome
Protein
Coat
-Slime Coat on some
bacteria
wall
-cell
-cell membrane

Sign up to see the contentIt's free!

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Improve your grades

Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Connective Tissue

Connective tissue is your body's structural framework, found in tendons, ligaments, and cartilage. It fills spaces between organs and tissues whilst providing essential structural support throughout your body.

This tissue type is incredibly versatile, adapting to provide exactly the right amount of support where needed. Whether it's the tough tendons connecting muscle to bone or the flexible cartilage cushioning your joints, connective tissue keeps everything properly positioned and functioning.

Remember: Connective tissue literally connects and supports - the name tells you exactly what it does!

We thought you’d never ask...

What is the Knowunity AI companion?

Our AI Companion is a student-focused AI tool that offers more than just answers. Built on millions of Knowunity resources, it provides relevant information, personalised study plans, quizzes, and content directly in the chat, adapting to your individual learning journey.

Where can I download the Knowunity app?

You can download the app from Google Play Store and Apple App Store.

Is Knowunity really free of charge?

That's right! Enjoy free access to study content, connect with fellow students, and get instant help – all at your fingertips.

15

Smart Tools NEW

Transform this note into: ✓ 50+ Practice Questions ✓ Interactive Flashcards ✓ Full Mock Exam ✓ Essay Outlines

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Quiz
Flashcards
Essay

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The app is very easy to use and well designed. I have found everything I was looking for so far and have been able to learn a lot from the presentations! I will definitely use the app for a class assignment! And of course it also helps a lot as an inspiration.

Stefan S

iOS user

This app is really great. There are so many study notes and help [...]. My problem subject is French, for example, and the app has so many options for help. Thanks to this app, I have improved my French. I would recommend it to anyone.

Samantha Klich

Android user

Wow, I am really amazed. I just tried the app because I've seen it advertised many times and was absolutely stunned. This app is THE HELP you want for school and above all, it offers so many things, such as workouts and fact sheets, which have been VERY helpful to me personally.

Anna

iOS user

Best app on earth! no words because it’s too good

Thomas R

iOS user

Just amazing. Let's me revise 10x better, this app is a quick 10/10. I highly recommend it to anyone. I can watch and search for notes. I can save them in the subject folder. I can revise it any time when I come back. If you haven't tried this app, you're really missing out.

Basil

Android user

This app has made me feel so much more confident in my exam prep, not only through boosting my own self confidence through the features that allow you to connect with others and feel less alone, but also through the way the app itself is centred around making you feel better. It is easy to navigate, fun to use, and helpful to anyone struggling in absolutely any way.

David K

iOS user

The app's just great! All I have to do is enter the topic in the search bar and I get the response real fast. I don't have to watch 10 YouTube videos to understand something, so I'm saving my time. Highly recommended!

Sudenaz Ocak

Android user

In school I was really bad at maths but thanks to the app, I am doing better now. I am so grateful that you made the app.

Greenlight Bonnie

Android user

very reliable app to help and grow your ideas of Maths, English and other related topics in your works. please use this app if your struggling in areas, this app is key for that. wish I'd of done a review before. and it's also free so don't worry about that.

Rohan U

Android user

I know a lot of apps use fake accounts to boost their reviews but this app deserves it all. Originally I was getting 4 in my English exams and this time I got a grade 7. I didn’t even know about this app three days until the exam and it has helped A LOT. Please actually trust me and use it as I’m sure you too will see developments.

Xander S

iOS user

THE QUIZES AND FLASHCARDS ARE SO USEFUL AND I LOVE THE SCHOOLGPT. IT ALSO IS LITREALLY LIKE CHATGPT BUT SMARTER!! HELPED ME WITH MY MASCARA PROBLEMS TOO!! AS WELL AS MY REAL SUBJECTS ! DUHHH 😍😁😲🤑💗✨🎀😮

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This apps acc the goat. I find revision so boring but this app makes it so easy to organize it all and then you can ask the freeeee ai to test yourself so good and you can easily upload your own stuff. highly recommend as someone taking mocks now

Paul T

iOS user

The app is very easy to use and well designed. I have found everything I was looking for so far and have been able to learn a lot from the presentations! I will definitely use the app for a class assignment! And of course it also helps a lot as an inspiration.

Stefan S

iOS user

This app is really great. There are so many study notes and help [...]. My problem subject is French, for example, and the app has so many options for help. Thanks to this app, I have improved my French. I would recommend it to anyone.

Samantha Klich

Android user

Wow, I am really amazed. I just tried the app because I've seen it advertised many times and was absolutely stunned. This app is THE HELP you want for school and above all, it offers so many things, such as workouts and fact sheets, which have been VERY helpful to me personally.

Anna

iOS user

Best app on earth! no words because it’s too good

Thomas R

iOS user

Just amazing. Let's me revise 10x better, this app is a quick 10/10. I highly recommend it to anyone. I can watch and search for notes. I can save them in the subject folder. I can revise it any time when I come back. If you haven't tried this app, you're really missing out.

Basil

Android user

This app has made me feel so much more confident in my exam prep, not only through boosting my own self confidence through the features that allow you to connect with others and feel less alone, but also through the way the app itself is centred around making you feel better. It is easy to navigate, fun to use, and helpful to anyone struggling in absolutely any way.

David K

iOS user

The app's just great! All I have to do is enter the topic in the search bar and I get the response real fast. I don't have to watch 10 YouTube videos to understand something, so I'm saving my time. Highly recommended!

Sudenaz Ocak

Android user

In school I was really bad at maths but thanks to the app, I am doing better now. I am so grateful that you made the app.

Greenlight Bonnie

Android user

very reliable app to help and grow your ideas of Maths, English and other related topics in your works. please use this app if your struggling in areas, this app is key for that. wish I'd of done a review before. and it's also free so don't worry about that.

Rohan U

Android user

I know a lot of apps use fake accounts to boost their reviews but this app deserves it all. Originally I was getting 4 in my English exams and this time I got a grade 7. I didn’t even know about this app three days until the exam and it has helped A LOT. Please actually trust me and use it as I’m sure you too will see developments.

Xander S

iOS user

THE QUIZES AND FLASHCARDS ARE SO USEFUL AND I LOVE THE SCHOOLGPT. IT ALSO IS LITREALLY LIKE CHATGPT BUT SMARTER!! HELPED ME WITH MY MASCARA PROBLEMS TOO!! AS WELL AS MY REAL SUBJECTS ! DUHHH 😍😁😲🤑💗✨🎀😮

Elisha

iOS user

This apps acc the goat. I find revision so boring but this app makes it so easy to organize it all and then you can ask the freeeee ai to test yourself so good and you can easily upload your own stuff. highly recommend as someone taking mocks now

Paul T

iOS user