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6 Dec 2025

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Cellular Respiration Summary for Biology 2.2

M

Molly

@molly_rife

Cellular respiration is your body's way of breaking down glucose... Show more

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## 2.2 Cellular Respiration

Definitions

Cellular respiration is a series of enzyme controlled reactions in which a
respiration substrate s

Cellular Respiration Overview and Glycolysis

Cellular respiration involves three key pathways that work together like a factory assembly line: glycolysis, the citric acid cycle, and the electron transport chain. Each stage builds on the previous one to maximise energy production from glucose.

Glycolysis kicks off in the cytoplasm, where glucose gets broken down into two pyruvate molecules. It's a bit like making an investment - you spend 2 ATP molecules upfront during the energy investment phase, but you get 4 ATP back during the energy payoff stage.

This gives you a net gain of 2 ATP molecules per glucose. The process involves phosphorylation (adding phosphate groups) to make glucose unstable, followed by lysis (splitting) and oxidation reactions that generate NADH molecules.

Key Point: Glycolysis happens in the cytoplasm, produces a net 2 ATP, and doesn't need oxygen - making it crucial for both aerobic and anaerobic conditions.

## 2.2 Cellular Respiration

Definitions

Cellular respiration is a series of enzyme controlled reactions in which a
respiration substrate s

Fermentation and Citric Acid Cycle

When oxygen runs short, fermentation becomes your backup plan. In your muscle cells, pyruvate converts to lactate (causing that burning sensation during intense exercise), whilst in yeast and plants, it becomes ethanol and carbon dioxide.

However, fermentation only produces 2 ATP molecules total - far less efficient than the 38 ATP from complete aerobic respiration. It's like choosing a bicycle over a car for a long journey.

The citric acid cycle operates in the mitochondrial matrix when oxygen is available. Pyruvate first transforms into acetyl CoA, then combines with oxaloacetate to form citrate. Through enzyme-controlled reactions, citrate cycles back to oxaloacetate, generating ATP, NADH, and carbon dioxide.

Remember: The citric acid cycle is like a recycling plant - oxaloacetate gets regenerated to keep the process running continuously.

## 2.2 Cellular Respiration

Definitions

Cellular respiration is a series of enzyme controlled reactions in which a
respiration substrate s

Electron Transport Chain

The electron transport chain is where cellular respiration reaches its peak efficiency. Located on the inner mitochondrial membrane (cristae), this series of carrier proteins works like a hydroelectric dam.

Electrons from NADH and FADH₂ pass along the chain, releasing energy that pumps hydrogen ions across the membrane. This creates a concentration gradient - imagine water building up behind a dam.

When these hydrogen ions flow back through ATP synthase, they drive ATP production. Oxygen acts as the final electron acceptor, combining with electrons and hydrogen ions to form water.

The electron transport chain produces the most ATP in cellular respiration - about 34 molecules per glucose.

Crucial Concept: Oxygen is essential here as the final electron acceptor. Without it, the entire chain stops, and cells must rely on much less efficient fermentation.

## 2.2 Cellular Respiration

Definitions

Cellular respiration is a series of enzyme controlled reactions in which a
respiration substrate s

Role of ATP in Cellular Processes

ATP functions as your body's universal energy currency, transferring power to processes that keep you alive and active. Every cellular activity that requires energy depends on ATP breakdown into ADP and phosphate.

Key examples include nerve transmission (sending signals through your nervous system), muscle contraction (enabling movement), and active transport (moving substances against concentration gradients).

The beauty of this system lies in its cycle - ATP breaks down to release energy for cellular work, then gets rebuilt through cellular respiration. It's like having a rechargeable battery that never wears out.

Think of cellular respiration as your body's power grid: glucose and oxygen go in, carbon dioxide and water come out, and ATP provides the energy for everything in between.

Essential Understanding: ATP is the link between energy-releasing processes (like cellular respiration) and energy-requiring processes (like muscle contraction and nerve transmission).

## 2.2 Cellular Respiration

Definitions

Cellular respiration is a series of enzyme controlled reactions in which a
respiration substrate s


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Just amazing. Let's me revise 10x better, this app is a quick 10/10. I highly recommend it to anyone. I can watch and search for notes. I can save them in the subject folder. I can revise it any time when I come back. If you haven't tried this app, you're really missing out.

Basil

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This app has made me feel so much more confident in my exam prep, not only through boosting my own self confidence through the features that allow you to connect with others and feel less alone, but also through the way the app itself is centred around making you feel better. It is easy to navigate, fun to use, and helpful to anyone struggling in absolutely any way.

David K

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Sudenaz Ocak

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In school I was really bad at maths but thanks to the app, I am doing better now. I am so grateful that you made the app.

Greenlight Bonnie

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very reliable app to help and grow your ideas of Maths, English and other related topics in your works. please use this app if your struggling in areas, this app is key for that. wish I'd of done a review before. and it's also free so don't worry about that.

Rohan U

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I know a lot of apps use fake accounts to boost their reviews but this app deserves it all. Originally I was getting 4 in my English exams and this time I got a grade 7. I didn’t even know about this app three days until the exam and it has helped A LOT. Please actually trust me and use it as I’m sure you too will see developments.

Xander S

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THE QUIZES AND FLASHCARDS ARE SO USEFUL AND I LOVE THE SCHOOLGPT. IT ALSO IS LITREALLY LIKE CHATGPT BUT SMARTER!! HELPED ME WITH MY MASCARA PROBLEMS TOO!! AS WELL AS MY REAL SUBJECTS ! DUHHH 😍😁😲🤑💗✨🎀😮

Elisha

iOS user

This apps acc the goat. I find revision so boring but this app makes it so easy to organize it all and then you can ask the freeeee ai to test yourself so good and you can easily upload your own stuff. highly recommend as someone taking mocks now

Paul T

iOS user

The app is very easy to use and well designed. I have found everything I was looking for so far and have been able to learn a lot from the presentations! I will definitely use the app for a class assignment! And of course it also helps a lot as an inspiration.

Stefan S

iOS user

This app is really great. There are so many study notes and help [...]. My problem subject is French, for example, and the app has so many options for help. Thanks to this app, I have improved my French. I would recommend it to anyone.

Samantha Klich

Android user

Wow, I am really amazed. I just tried the app because I've seen it advertised many times and was absolutely stunned. This app is THE HELP you want for school and above all, it offers so many things, such as workouts and fact sheets, which have been VERY helpful to me personally.

Anna

iOS user

Best app on earth! no words because it’s too good

Thomas R

iOS user

Just amazing. Let's me revise 10x better, this app is a quick 10/10. I highly recommend it to anyone. I can watch and search for notes. I can save them in the subject folder. I can revise it any time when I come back. If you haven't tried this app, you're really missing out.

Basil

Android user

This app has made me feel so much more confident in my exam prep, not only through boosting my own self confidence through the features that allow you to connect with others and feel less alone, but also through the way the app itself is centred around making you feel better. It is easy to navigate, fun to use, and helpful to anyone struggling in absolutely any way.

David K

iOS user

The app's just great! All I have to do is enter the topic in the search bar and I get the response real fast. I don't have to watch 10 YouTube videos to understand something, so I'm saving my time. Highly recommended!

Sudenaz Ocak

Android user

In school I was really bad at maths but thanks to the app, I am doing better now. I am so grateful that you made the app.

Greenlight Bonnie

Android user

very reliable app to help and grow your ideas of Maths, English and other related topics in your works. please use this app if your struggling in areas, this app is key for that. wish I'd of done a review before. and it's also free so don't worry about that.

Rohan U

Android user

I know a lot of apps use fake accounts to boost their reviews but this app deserves it all. Originally I was getting 4 in my English exams and this time I got a grade 7. I didn’t even know about this app three days until the exam and it has helped A LOT. Please actually trust me and use it as I’m sure you too will see developments.

Xander S

iOS user

THE QUIZES AND FLASHCARDS ARE SO USEFUL AND I LOVE THE SCHOOLGPT. IT ALSO IS LITREALLY LIKE CHATGPT BUT SMARTER!! HELPED ME WITH MY MASCARA PROBLEMS TOO!! AS WELL AS MY REAL SUBJECTS ! DUHHH 😍😁😲🤑💗✨🎀😮

Elisha

iOS user

This apps acc the goat. I find revision so boring but this app makes it so easy to organize it all and then you can ask the freeeee ai to test yourself so good and you can easily upload your own stuff. highly recommend as someone taking mocks now

Paul T

iOS user

 

Biology

191

6 Dec 2025

5 pages

Cellular Respiration Summary for Biology 2.2

M

Molly

@molly_rife

Cellular respiration is your body's way of breaking down glucose to create ATP - the energy currency that powers everything from your heartbeat to your thoughts. Think of it as your cellular power station, running three main processes that transform... Show more

## 2.2 Cellular Respiration

Definitions

Cellular respiration is a series of enzyme controlled reactions in which a
respiration substrate s

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Cellular Respiration Overview and Glycolysis

Cellular respiration involves three key pathways that work together like a factory assembly line: glycolysis, the citric acid cycle, and the electron transport chain. Each stage builds on the previous one to maximise energy production from glucose.

Glycolysis kicks off in the cytoplasm, where glucose gets broken down into two pyruvate molecules. It's a bit like making an investment - you spend 2 ATP molecules upfront during the energy investment phase, but you get 4 ATP back during the energy payoff stage.

This gives you a net gain of 2 ATP molecules per glucose. The process involves phosphorylation (adding phosphate groups) to make glucose unstable, followed by lysis (splitting) and oxidation reactions that generate NADH molecules.

Key Point: Glycolysis happens in the cytoplasm, produces a net 2 ATP, and doesn't need oxygen - making it crucial for both aerobic and anaerobic conditions.

## 2.2 Cellular Respiration

Definitions

Cellular respiration is a series of enzyme controlled reactions in which a
respiration substrate s

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Fermentation and Citric Acid Cycle

When oxygen runs short, fermentation becomes your backup plan. In your muscle cells, pyruvate converts to lactate (causing that burning sensation during intense exercise), whilst in yeast and plants, it becomes ethanol and carbon dioxide.

However, fermentation only produces 2 ATP molecules total - far less efficient than the 38 ATP from complete aerobic respiration. It's like choosing a bicycle over a car for a long journey.

The citric acid cycle operates in the mitochondrial matrix when oxygen is available. Pyruvate first transforms into acetyl CoA, then combines with oxaloacetate to form citrate. Through enzyme-controlled reactions, citrate cycles back to oxaloacetate, generating ATP, NADH, and carbon dioxide.

Remember: The citric acid cycle is like a recycling plant - oxaloacetate gets regenerated to keep the process running continuously.

## 2.2 Cellular Respiration

Definitions

Cellular respiration is a series of enzyme controlled reactions in which a
respiration substrate s

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Electron Transport Chain

The electron transport chain is where cellular respiration reaches its peak efficiency. Located on the inner mitochondrial membrane (cristae), this series of carrier proteins works like a hydroelectric dam.

Electrons from NADH and FADH₂ pass along the chain, releasing energy that pumps hydrogen ions across the membrane. This creates a concentration gradient - imagine water building up behind a dam.

When these hydrogen ions flow back through ATP synthase, they drive ATP production. Oxygen acts as the final electron acceptor, combining with electrons and hydrogen ions to form water.

The electron transport chain produces the most ATP in cellular respiration - about 34 molecules per glucose.

Crucial Concept: Oxygen is essential here as the final electron acceptor. Without it, the entire chain stops, and cells must rely on much less efficient fermentation.

## 2.2 Cellular Respiration

Definitions

Cellular respiration is a series of enzyme controlled reactions in which a
respiration substrate s

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Role of ATP in Cellular Processes

ATP functions as your body's universal energy currency, transferring power to processes that keep you alive and active. Every cellular activity that requires energy depends on ATP breakdown into ADP and phosphate.

Key examples include nerve transmission (sending signals through your nervous system), muscle contraction (enabling movement), and active transport (moving substances against concentration gradients).

The beauty of this system lies in its cycle - ATP breaks down to release energy for cellular work, then gets rebuilt through cellular respiration. It's like having a rechargeable battery that never wears out.

Think of cellular respiration as your body's power grid: glucose and oxygen go in, carbon dioxide and water come out, and ATP provides the energy for everything in between.

Essential Understanding: ATP is the link between energy-releasing processes (like cellular respiration) and energy-requiring processes (like muscle contraction and nerve transmission).

## 2.2 Cellular Respiration

Definitions

Cellular respiration is a series of enzyme controlled reactions in which a
respiration substrate s

Sign up to see the contentIt's free!

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Improve your grades

Join milions of students

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We thought you’d never ask...

What is the Knowunity AI companion?

Our AI Companion is a student-focused AI tool that offers more than just answers. Built on millions of Knowunity resources, it provides relevant information, personalised study plans, quizzes, and content directly in the chat, adapting to your individual learning journey.

Where can I download the Knowunity app?

You can download the app from Google Play Store and Apple App Store.

Is Knowunity really free of charge?

That's right! Enjoy free access to study content, connect with fellow students, and get instant help – all at your fingertips.

Most popular content: Cellular Respiration

Most popular content in Biology

Most popular content

English - inspector calls quotes and analysis

Quotes from every main character

English LiteratureEnglish Literature
10

Can't find what you're looking for? Explore other subjects.

Students love us — and so will you.

4.9/5

App Store

4.8/5

Google Play

The app is very easy to use and well designed. I have found everything I was looking for so far and have been able to learn a lot from the presentations! I will definitely use the app for a class assignment! And of course it also helps a lot as an inspiration.

Stefan S

iOS user

This app is really great. There are so many study notes and help [...]. My problem subject is French, for example, and the app has so many options for help. Thanks to this app, I have improved my French. I would recommend it to anyone.

Samantha Klich

Android user

Wow, I am really amazed. I just tried the app because I've seen it advertised many times and was absolutely stunned. This app is THE HELP you want for school and above all, it offers so many things, such as workouts and fact sheets, which have been VERY helpful to me personally.

Anna

iOS user

Best app on earth! no words because it’s too good

Thomas R

iOS user

Just amazing. Let's me revise 10x better, this app is a quick 10/10. I highly recommend it to anyone. I can watch and search for notes. I can save them in the subject folder. I can revise it any time when I come back. If you haven't tried this app, you're really missing out.

Basil

Android user

This app has made me feel so much more confident in my exam prep, not only through boosting my own self confidence through the features that allow you to connect with others and feel less alone, but also through the way the app itself is centred around making you feel better. It is easy to navigate, fun to use, and helpful to anyone struggling in absolutely any way.

David K

iOS user

The app's just great! All I have to do is enter the topic in the search bar and I get the response real fast. I don't have to watch 10 YouTube videos to understand something, so I'm saving my time. Highly recommended!

Sudenaz Ocak

Android user

In school I was really bad at maths but thanks to the app, I am doing better now. I am so grateful that you made the app.

Greenlight Bonnie

Android user

very reliable app to help and grow your ideas of Maths, English and other related topics in your works. please use this app if your struggling in areas, this app is key for that. wish I'd of done a review before. and it's also free so don't worry about that.

Rohan U

Android user

I know a lot of apps use fake accounts to boost their reviews but this app deserves it all. Originally I was getting 4 in my English exams and this time I got a grade 7. I didn’t even know about this app three days until the exam and it has helped A LOT. Please actually trust me and use it as I’m sure you too will see developments.

Xander S

iOS user

THE QUIZES AND FLASHCARDS ARE SO USEFUL AND I LOVE THE SCHOOLGPT. IT ALSO IS LITREALLY LIKE CHATGPT BUT SMARTER!! HELPED ME WITH MY MASCARA PROBLEMS TOO!! AS WELL AS MY REAL SUBJECTS ! DUHHH 😍😁😲🤑💗✨🎀😮

Elisha

iOS user

This apps acc the goat. I find revision so boring but this app makes it so easy to organize it all and then you can ask the freeeee ai to test yourself so good and you can easily upload your own stuff. highly recommend as someone taking mocks now

Paul T

iOS user

The app is very easy to use and well designed. I have found everything I was looking for so far and have been able to learn a lot from the presentations! I will definitely use the app for a class assignment! And of course it also helps a lot as an inspiration.

Stefan S

iOS user

This app is really great. There are so many study notes and help [...]. My problem subject is French, for example, and the app has so many options for help. Thanks to this app, I have improved my French. I would recommend it to anyone.

Samantha Klich

Android user

Wow, I am really amazed. I just tried the app because I've seen it advertised many times and was absolutely stunned. This app is THE HELP you want for school and above all, it offers so many things, such as workouts and fact sheets, which have been VERY helpful to me personally.

Anna

iOS user

Best app on earth! no words because it’s too good

Thomas R

iOS user

Just amazing. Let's me revise 10x better, this app is a quick 10/10. I highly recommend it to anyone. I can watch and search for notes. I can save them in the subject folder. I can revise it any time when I come back. If you haven't tried this app, you're really missing out.

Basil

Android user

This app has made me feel so much more confident in my exam prep, not only through boosting my own self confidence through the features that allow you to connect with others and feel less alone, but also through the way the app itself is centred around making you feel better. It is easy to navigate, fun to use, and helpful to anyone struggling in absolutely any way.

David K

iOS user

The app's just great! All I have to do is enter the topic in the search bar and I get the response real fast. I don't have to watch 10 YouTube videos to understand something, so I'm saving my time. Highly recommended!

Sudenaz Ocak

Android user

In school I was really bad at maths but thanks to the app, I am doing better now. I am so grateful that you made the app.

Greenlight Bonnie

Android user

very reliable app to help and grow your ideas of Maths, English and other related topics in your works. please use this app if your struggling in areas, this app is key for that. wish I'd of done a review before. and it's also free so don't worry about that.

Rohan U

Android user

I know a lot of apps use fake accounts to boost their reviews but this app deserves it all. Originally I was getting 4 in my English exams and this time I got a grade 7. I didn’t even know about this app three days until the exam and it has helped A LOT. Please actually trust me and use it as I’m sure you too will see developments.

Xander S

iOS user

THE QUIZES AND FLASHCARDS ARE SO USEFUL AND I LOVE THE SCHOOLGPT. IT ALSO IS LITREALLY LIKE CHATGPT BUT SMARTER!! HELPED ME WITH MY MASCARA PROBLEMS TOO!! AS WELL AS MY REAL SUBJECTS ! DUHHH 😍😁😲🤑💗✨🎀😮

Elisha

iOS user

This apps acc the goat. I find revision so boring but this app makes it so easy to organize it all and then you can ask the freeeee ai to test yourself so good and you can easily upload your own stuff. highly recommend as someone taking mocks now

Paul T

iOS user