Biology281Updated 19 Sept 20261 page

Biology Topic 3: Infection and Response (AQA Combined Science)

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Charlotte@charlotte26
Your body is constantly under attack from harmful microorganisms, but you've got some pretty amazing defences to keep you healthy. Understanding how pathogens cause disease and how your immune system fights back is crucial for GCSE Biology - and it'll help you make sense of everything from why you need to wash your hands to how vaccines actually work.
Infection and Response Biology Topic 3 – page 1

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Human Body Defences and Pathogens

Think of your body as a fortress with multiple layers of protection against invaders. Your non-specific defences work like the outer walls - they stop most threats before they even get inside. Your skin acts as a waterproof barrier, whilst mucus in your respiratory system traps pathogens trying to enter through your airways.

Your body's got some clever chemical warfare too. Tears contain enzymes that destroy pathogens threatening your eyes, and your stomach produces hydrochloric acid that kills most nasties you accidentally swallow. Even your skin hosts good bacteria that crowd out the harmful ones.

Pathogens are disease-causing microorganisms including bacteria, viruses, fungi, and protists. Communicable diseases spread from person to person through direct contact, air, water, contaminated food, or vectors like mosquitoes. Non-communicable diseases, however, can't be passed between people.

Key Insight: Your body's first line of defence works 24/7 without you even thinking about it - pretty impressive for something you never have to consciously control!

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