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Understanding Gene Expression and DNA Mutations for A Level Biology

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Hameedah

10/07/2023

Biology

Topic 8 The control of gene expression

Understanding Gene Expression and DNA Mutations for A Level Biology

Gene expression and mutations are fundamental concepts in molecular biology that determine how genetic information is used and modified within cells.

Control of gene expression involves multiple regulatory mechanisms that determine when and how genes are activated or repressed. Transcription factors play a crucial role by binding to specific DNA sequences to either promote or inhibit gene expression. One important example is Oestrogen, which acts as a transcription factor in human cells by binding to specific response elements. Epigenetics represents another layer of control through chemical modifications like acetylation of histones, which can alter DNA accessibility without changing the genetic code itself.

DNA mutations can significantly impact protein structure and function through various mechanisms. Substitution mutations involve the replacement of one nucleotide with another, while insertion mutations and deletion mutations add or remove nucleotides respectively. These changes can lead to different outcomes: missense mutations alter the amino acid sequence, potentially affecting protein folding and function. Frameshift mutations occur when the number of inserted or deleted nucleotides isn't divisible by three, disrupting the entire reading frame. The consequences of mutations can be classified as either gain-of-function mutations, where proteins acquire new or enhanced activities, or loss-of-function mutations, where protein function is reduced or eliminated. Common examples in humans include sickle cell anemia (caused by a substitution mutation) and cystic fibrosis (often resulting from a deletion mutation). Understanding these concepts is crucial for medical research and genetic counseling, as mutations can lead to various genetic disorders and diseases. The impact of mutations on protein structure and function depends on factors such as the location of the mutation, the type of amino acid change, and the importance of the affected region for protein function.

...

10/07/2023

1040

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

View

Types of DNA Mutations (Continued)

This page continues the discussion on DNA mutations, focusing on more complex types and their effects.

Duplication Mutations:

  • One or more bases are repeated, causing a frame shift
  • Similar effect to insertion mutations

Inversion Mutations:

  • A group of bases becomes separated and rejoins in reverse order
  • Alters amino acid sequence and protein structure

Translocation Mutations:

  • Groups of bases move from one chromosome to another
  • Can have significant phenotypic effects due to gene relocation

Example: Chronic myeloid leukemia is caused by a translocation between chromosomes 9 and 22, resulting in a hybrid protein that promotes uncontrolled cell division.

Nonsense Mutations:

  • Produce a premature stop codon, leading to a non-functional protein

Example: Duchenne muscular dystrophy is caused by nonsense mutations in the dystrophin gene, affecting muscle cell structure and function.

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

View

Causes of Mutations and Their Effects

This section explores the various causes of DNA mutations and their potential impacts on organisms.

Causes of Mutations:

  • Spontaneous errors during DNA replication
  • Chemical mutagens e.g.,benzene,alcohol,asbestos,tobaccoe.g., benzene, alcohol, asbestos, tobacco
  • Ionizing radiation UV,Xrays,alphaandbetaradiationUV, X-rays, alpha and beta radiation

Effects of Mutations:

  • Neutral: No change to the organism
  • Beneficial: e.g., antibiotic resistance in bacteria fromthebacteriasperspectivefrom the bacteria's perspective
  • Harmful: e.g., mutations in the CFTR protein causing cystic fibrosis

Highlight: The impact of a mutation can vary greatly, from having no effect to causing significant changes in an organism's phenotype and fitness.

Gene Expression Control:

  • Most of a cell's DNA is not translated
  • Gene expression is regulated by various features

Definition: Gene expression is the process by which information from a gene is used to synthesize a functional gene product, usually a protein.

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

View

Stem Cells and Cell Differentiation

This page introduces the concept of stem cells and their role in cell differentiation and specialization.

Stem Cells:

  • Undifferentiated cells capable of continuous division and specialization

Types of Stem Cells:

  1. Totipotent Cells: Can produce any type of body cell Present only for a limited time in early mammalian embryos Translate only part of their DNA during development, leading to cell specialization
  2. Pluripotent Cells: Found in embryos Can divide indefinitely and differentiate into almost any cell type Used in treating human disorders e.g.,skincellregrowth,betacellsfortype1diabetese.g., skin cell regrowth, beta cells for type 1 diabetes Cannot form extra-embryonic cells

Highlight: Pluripotent stem cells offer great potential for regenerative medicine but also raise ethical concerns.

  1. Multipotent Cells: Found in mature mammals Can differentiate into multiple, but limited, cell types e.g.,bonemarrowcellse.g., bone marrow cells
  2. Unipotent Cells: Found in mature mammals Can only differentiate into one cell type e.g.,cardiomyocytese.g., cardiomyocytes

Induced Pluripotent Stem IPSIPS Cells:

  • Created from adult unipotent cells somaticcellssomatic cells
  • Treated with transcription factors to induce pluripotency

Vocabulary: Transcription factors are proteins that regulate gene expression by binding to specific DNA sequences.

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

View

Page 5: Mutation Causes and Gene Expression

The page explores various causes of mutations and introduces gene expression control.

Vocabulary: Chemical mutagens - Substances that can cause DNA mutations, including benzene, alcohol, and tobacco.

Definition: Stem cells are undifferentiated cells capable of continuous division and specialization.

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

View

Understanding DNA Mutations and Their Effects

DNA mutations can significantly alter genetic information and protein function through various mechanisms. The original DNA sequence TGCCTA can undergo several types of mutations that affect protein structure and function in different ways.

Definition: A mutation is any change in the nucleotide sequence of DNA that can affect protein structure and function. These changes can be spontaneous or induced by environmental factors.

The main types of mutations include substitution mutations, where one base is replaced by another, insertion mutations that add nucleotides, and deletion mutations that remove nucleotides. These changes can occur due to several factors:

  • Spontaneous errors during DNA replication
  • Chemical mutagens like benzene, alcohol, asbestos, and tobacco
  • Ionizing radiation including UV rays whichcancauseneighboringthyminebasestojoinwhich can cause neighboring thymine bases to join, X-rays, and other forms of radiation

Example: In a substitution mutation, TGCCTA might become TGACTA, potentially changing the amino acid coded for at that position. A deletion mutation could transform TGCCTA to TGCTA, causing a frameshift in the reading frame.

The effects of mutations can vary significantly:

  • Neutral mutations cause no observable change in the organism
  • Beneficial mutations may provide advantages like antibiotic resistance in bacteria
  • Harmful mutations can cause genetic disorders, such as mutations in the CFTR protein leading to cystic fibrosis
8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

View

Control of Gene Expression and Stem Cells

Gene expression control is fundamental to cellular differentiation and specialization. This process involves complex mechanisms that determine which genes are activated or repressed.

Vocabulary: Stem cells are undifferentiated cells with the ability to continuously divide and become specialized. They exist in different forms with varying potency levels.

The hierarchy of stem cells includes:

  • Totipotent cells: Can produce any type of body cell
  • Pluripotent cells: Can differentiate into almost any cell type but cannot form extra-embryonic tissues
  • Multipotent cells: Can form multiple but limited cell types
  • Unipotent cells: Can only differentiate into one specific cell type

Highlight: Induced Pluripotent Stem IPSIPS cells are created from adult unipotent cells through treatment with specific transcription factors. These cells offer advantages over embryonic stem cells as they don't involve embryonic destruction and provide unlimited self-renewal capacity.

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

View

Transcription Regulation and Epigenetic Control

Transcription factors play a crucial role in gene regulation by either inhibiting or stimulating gene expression. These molecular switches help determine cell specialization and function.

Definition: Epigenetics refers to heritable changes in gene function without alterations to the DNA sequence itself. These changes are influenced by environmental factors and can affect gene expression.

Key epigenetic mechanisms include:

  • DNA methylation: Addition of methyl groups to cytosine bases prevents transcription factor binding
  • Histone acetylation: Affects chromatin structure and accessibility for transcription
  • RNA interference: Can inhibit translation of specific mRNAs

Example: Oestrogen acts as a transcription factor by binding to receptor molecules and altering their shape, enabling DNA binding and gene activation.

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

View

Disease Treatment and Genetic Modification

Understanding genetic control mechanisms has led to innovative treatment approaches for various diseases, particularly cancer.

Highlight: Epigenetic modifications can be targeted therapeutically:

  • Drugs reducing DNA methylation can treat cancers caused by hypermethylation of tumor suppressor genes
  • Controlling histone acetylation can influence gene expression patterns

Treatment considerations include:

  • Specificity of targeting cancer cells while protecting healthy cells
  • Development of drugs that can effectively modify epigenetic marks
  • Understanding the complex interplay between different regulatory mechanisms

The challenge lies in developing precise interventions that can selectively target disease-causing genetic modifications while maintaining normal cellular function.

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

View

Control of Gene Expression Through RNA Interference

RNA interference represents a sophisticated mechanism of Control of gene expression in a level biology where small RNA molecules regulate protein production. This process involves specific interactions between different types of RNA that ultimately prevent certain genes from being expressed.

When small RNA strands bind to messenger RNA mRNAmRNA, they create a double-stranded structure that effectively blocks translation. This interference mechanism is particularly important in gene regulation and has become a crucial area of study in Control of gene expression a level Biology OCR and other examination boards. The process demonstrates how cells can fine-tune their protein production without altering the DNA sequence itself.

Small interfering RNA siRNAsiRNA plays a central role in this regulatory process. These specialized RNA molecules work through a precise mechanism where double-stranded siRNA molecules first interact with specific proteins in the cytoplasm. After unwinding, the siRNA-enzyme complex seeks out and binds to complementary sequences on target mRNA molecules. The remarkable specificity of siRNA means each type can only interact with its corresponding mRNA sequence, making it an extremely precise regulatory tool.

Definition: RNA interference RNAiRNAi is a biological process where RNA molecules inhibit gene expression by neutralizing targeted mRNA molecules, preventing them from being translated into proteins.

The final stage of this process involves the degradation of the target mRNA. Once the siRNA-enzyme complex binds to its target, specialized proteins associated with the complex cut the mRNA into smaller fragments. These fragments are then transported to cellular structures called processing bodies, where they undergo complete degradation. This mechanism represents a critical form of post-transcriptional gene regulation that cells use to control protein production.

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Biology

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23 Jun 2025

27 pages

Understanding Gene Expression and DNA Mutations for A Level Biology

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Hameedah

@hameedah

Gene expression and mutations are fundamental concepts in molecular biology that determine how genetic information is used and modified within cells.

Control of gene expression involves multiple regulatory mechanisms that determine when and how genes are activated or repressed. Transcription... Show more

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

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Types of DNA Mutations (Continued)

This page continues the discussion on DNA mutations, focusing on more complex types and their effects.

Duplication Mutations:

  • One or more bases are repeated, causing a frame shift
  • Similar effect to insertion mutations

Inversion Mutations:

  • A group of bases becomes separated and rejoins in reverse order
  • Alters amino acid sequence and protein structure

Translocation Mutations:

  • Groups of bases move from one chromosome to another
  • Can have significant phenotypic effects due to gene relocation

Example: Chronic myeloid leukemia is caused by a translocation between chromosomes 9 and 22, resulting in a hybrid protein that promotes uncontrolled cell division.

Nonsense Mutations:

  • Produce a premature stop codon, leading to a non-functional protein

Example: Duchenne muscular dystrophy is caused by nonsense mutations in the dystrophin gene, affecting muscle cell structure and function.

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

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Causes of Mutations and Their Effects

This section explores the various causes of DNA mutations and their potential impacts on organisms.

Causes of Mutations:

  • Spontaneous errors during DNA replication
  • Chemical mutagens e.g.,benzene,alcohol,asbestos,tobaccoe.g., benzene, alcohol, asbestos, tobacco
  • Ionizing radiation UV,Xrays,alphaandbetaradiationUV, X-rays, alpha and beta radiation

Effects of Mutations:

  • Neutral: No change to the organism
  • Beneficial: e.g., antibiotic resistance in bacteria fromthebacteriasperspectivefrom the bacteria's perspective
  • Harmful: e.g., mutations in the CFTR protein causing cystic fibrosis

Highlight: The impact of a mutation can vary greatly, from having no effect to causing significant changes in an organism's phenotype and fitness.

Gene Expression Control:

  • Most of a cell's DNA is not translated
  • Gene expression is regulated by various features

Definition: Gene expression is the process by which information from a gene is used to synthesize a functional gene product, usually a protein.

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

Sign up to see the contentIt's free!

Access to all documents

Improve your grades

Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Stem Cells and Cell Differentiation

This page introduces the concept of stem cells and their role in cell differentiation and specialization.

Stem Cells:

  • Undifferentiated cells capable of continuous division and specialization

Types of Stem Cells:

  1. Totipotent Cells: Can produce any type of body cell Present only for a limited time in early mammalian embryos Translate only part of their DNA during development, leading to cell specialization
  2. Pluripotent Cells: Found in embryos Can divide indefinitely and differentiate into almost any cell type Used in treating human disorders e.g.,skincellregrowth,betacellsfortype1diabetese.g., skin cell regrowth, beta cells for type 1 diabetes Cannot form extra-embryonic cells

Highlight: Pluripotent stem cells offer great potential for regenerative medicine but also raise ethical concerns.

  1. Multipotent Cells: Found in mature mammals Can differentiate into multiple, but limited, cell types e.g.,bonemarrowcellse.g., bone marrow cells
  2. Unipotent Cells: Found in mature mammals Can only differentiate into one cell type e.g.,cardiomyocytese.g., cardiomyocytes

Induced Pluripotent Stem IPSIPS Cells:

  • Created from adult unipotent cells somaticcellssomatic cells
  • Treated with transcription factors to induce pluripotency

Vocabulary: Transcription factors are proteins that regulate gene expression by binding to specific DNA sequences.

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

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Page 5: Mutation Causes and Gene Expression

The page explores various causes of mutations and introduces gene expression control.

Vocabulary: Chemical mutagens - Substances that can cause DNA mutations, including benzene, alcohol, and tobacco.

Definition: Stem cells are undifferentiated cells capable of continuous division and specialization.

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

Sign up to see the contentIt's free!

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Improve your grades

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Understanding DNA Mutations and Their Effects

DNA mutations can significantly alter genetic information and protein function through various mechanisms. The original DNA sequence TGCCTA can undergo several types of mutations that affect protein structure and function in different ways.

Definition: A mutation is any change in the nucleotide sequence of DNA that can affect protein structure and function. These changes can be spontaneous or induced by environmental factors.

The main types of mutations include substitution mutations, where one base is replaced by another, insertion mutations that add nucleotides, and deletion mutations that remove nucleotides. These changes can occur due to several factors:

  • Spontaneous errors during DNA replication
  • Chemical mutagens like benzene, alcohol, asbestos, and tobacco
  • Ionizing radiation including UV rays whichcancauseneighboringthyminebasestojoinwhich can cause neighboring thymine bases to join, X-rays, and other forms of radiation

Example: In a substitution mutation, TGCCTA might become TGACTA, potentially changing the amino acid coded for at that position. A deletion mutation could transform TGCCTA to TGCTA, causing a frameshift in the reading frame.

The effects of mutations can vary significantly:

  • Neutral mutations cause no observable change in the organism
  • Beneficial mutations may provide advantages like antibiotic resistance in bacteria
  • Harmful mutations can cause genetic disorders, such as mutations in the CFTR protein leading to cystic fibrosis
8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

Sign up to see the contentIt's free!

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Improve your grades

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Control of Gene Expression and Stem Cells

Gene expression control is fundamental to cellular differentiation and specialization. This process involves complex mechanisms that determine which genes are activated or repressed.

Vocabulary: Stem cells are undifferentiated cells with the ability to continuously divide and become specialized. They exist in different forms with varying potency levels.

The hierarchy of stem cells includes:

  • Totipotent cells: Can produce any type of body cell
  • Pluripotent cells: Can differentiate into almost any cell type but cannot form extra-embryonic tissues
  • Multipotent cells: Can form multiple but limited cell types
  • Unipotent cells: Can only differentiate into one specific cell type

Highlight: Induced Pluripotent Stem IPSIPS cells are created from adult unipotent cells through treatment with specific transcription factors. These cells offer advantages over embryonic stem cells as they don't involve embryonic destruction and provide unlimited self-renewal capacity.

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

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Transcription Regulation and Epigenetic Control

Transcription factors play a crucial role in gene regulation by either inhibiting or stimulating gene expression. These molecular switches help determine cell specialization and function.

Definition: Epigenetics refers to heritable changes in gene function without alterations to the DNA sequence itself. These changes are influenced by environmental factors and can affect gene expression.

Key epigenetic mechanisms include:

  • DNA methylation: Addition of methyl groups to cytosine bases prevents transcription factor binding
  • Histone acetylation: Affects chromatin structure and accessibility for transcription
  • RNA interference: Can inhibit translation of specific mRNAs

Example: Oestrogen acts as a transcription factor by binding to receptor molecules and altering their shape, enabling DNA binding and gene activation.

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

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Disease Treatment and Genetic Modification

Understanding genetic control mechanisms has led to innovative treatment approaches for various diseases, particularly cancer.

Highlight: Epigenetic modifications can be targeted therapeutically:

  • Drugs reducing DNA methylation can treat cancers caused by hypermethylation of tumor suppressor genes
  • Controlling histone acetylation can influence gene expression patterns

Treatment considerations include:

  • Specificity of targeting cancer cells while protecting healthy cells
  • Development of drugs that can effectively modify epigenetic marks
  • Understanding the complex interplay between different regulatory mechanisms

The challenge lies in developing precise interventions that can selectively target disease-causing genetic modifications while maintaining normal cellular function.

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

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Control of Gene Expression Through RNA Interference

RNA interference represents a sophisticated mechanism of Control of gene expression in a level biology where small RNA molecules regulate protein production. This process involves specific interactions between different types of RNA that ultimately prevent certain genes from being expressed.

When small RNA strands bind to messenger RNA mRNAmRNA, they create a double-stranded structure that effectively blocks translation. This interference mechanism is particularly important in gene regulation and has become a crucial area of study in Control of gene expression a level Biology OCR and other examination boards. The process demonstrates how cells can fine-tune their protein production without altering the DNA sequence itself.

Small interfering RNA siRNAsiRNA plays a central role in this regulatory process. These specialized RNA molecules work through a precise mechanism where double-stranded siRNA molecules first interact with specific proteins in the cytoplasm. After unwinding, the siRNA-enzyme complex seeks out and binds to complementary sequences on target mRNA molecules. The remarkable specificity of siRNA means each type can only interact with its corresponding mRNA sequence, making it an extremely precise regulatory tool.

Definition: RNA interference RNAiRNAi is a biological process where RNA molecules inhibit gene expression by neutralizing targeted mRNA molecules, preventing them from being translated into proteins.

The final stage of this process involves the degradation of the target mRNA. Once the siRNA-enzyme complex binds to its target, specialized proteins associated with the complex cut the mRNA into smaller fragments. These fragments are then transported to cellular structures called processing bodies, where they undergo complete degradation. This mechanism represents a critical form of post-transcriptional gene regulation that cells use to control protein production.

8 The control of gene expression
EAS/A level A level
3.8.1 Alteration of the sequence of bases in DNA alters the structure of proteins
▾ Sub

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Mechanisms of Gene Silencing and Regulation

The control of gene expression through RNA interference demonstrates the complexity of cellular regulation systems. This mechanism is particularly relevant for students studying Control of gene expression in a level biology aqa and represents a key topic in Control of Gene Expression A Level Biology exam questions.

The process of gene silencing through RNA interference involves multiple steps and cellular components working in concert. The specificity of this system is remarkable - each siRNA molecule can target only one specific type of mRNA, making it an incredibly precise tool for gene regulation. This specificity is achieved through complementary base pairing, similar to how DNA strands match up with their complementary sequences.

Highlight: The specificity of siRNA binding is crucial for proper gene regulation - even a single mismatched base can prevent the silencing mechanism from working effectively.

Understanding RNA interference has significant practical applications in both research and medicine. Scientists can design synthetic siRNA molecules to target specific genes, allowing them to study gene function or potentially treat diseases caused by overactive genes. This application of RNA interference has become an important tool in modern molecular biology and represents a promising avenue for therapeutic interventions.

The degradation of target mRNA in processing bodies represents the final step in this regulatory mechanism. These specialized cellular compartments contain enzymes that break down the mRNA fragments, ensuring that the silencing effect is complete and permanent. This process demonstrates how cells can rapidly and effectively control gene expression at the post-transcriptional level.

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This app has made me feel so much more confident in my exam prep, not only through boosting my own self confidence through the features that allow you to connect with others and feel less alone, but also through the way the app itself is centred around making you feel better. It is easy to navigate, fun to use, and helpful to anyone struggling in absolutely any way.

David K

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Xander S

iOS user

THE QUIZES AND FLASHCARDS ARE SO USEFUL AND I LOVE THE SCHOOLGPT. IT ALSO IS LITREALLY LIKE CHATGPT BUT SMARTER!! HELPED ME WITH MY MASCARA PROBLEMS TOO!! AS WELL AS MY REAL SUBJECTS ! DUHHH 😍😁😲🤑💗✨🎀😮

Elisha

iOS user

This apps acc the goat. I find revision so boring but this app makes it so easy to organize it all and then you can ask the freeeee ai to test yourself so good and you can easily upload your own stuff. highly recommend as someone taking mocks now

Paul T

iOS user