Hyde's Disturbing Appearance and Jekyll's Will
Hyde's physical description is brilliantly unsettling because it's so vague. Enfield can't pinpoint what's wrong with him, just that there's "something displeasing, something down-right detestable" about his appearance. This suggests the problem isn't physical deformity but something deeper and more disturbing.
The revelation of Jekyll's will explains Utterson's concern perfectly. Dr Henry Jekyll - clearly a man of great learning and reputation (look at all those impressive letters after his name) - has left everything to Edward Hyde, including a bizarre clause about "disappearance or unexplained absence."
This will has always bothered Utterson as both a lawyer and a sensible man. Now that he knows Hyde is a violent, detestable person, his "indignation" has turned to genuine fear. The respectable Dr Jekyll is somehow connected to the monster who trampled a child.
The lawyer's decision to visit Dr Lanyon shows his methodical approach to solving this mystery. If anyone knows Jekyll's secrets, it would be an old friend from school and college days.
Character Analysis: Jekyll's academic credentials (M.D., D.C.L., L.L.D., F.R.S.) emphasise how shocking it is that such a learned, respectable man would be connected to someone like Hyde.