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Cell biology
Biological molecules
Organisation
Infection and response
Energy transfers (a2 only)
Homeostasis and response
Responding to change (a2 only)
The control of gene expression (a-level only)
Substance exchange
Bioenergetics
Genetic information & variation
Inheritance, variation and evolution
Genetics & ecosystems (a2 only)
Ecology
Cells
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1c the tudors: england, 1485-1603
1l the quest for political stability: germany, 1871-1991
Inter-war germany
1f industrialisation and the people: britain, c1783-1885
Britain & the wider world: 1745 -1901
2n revolution and dictatorship: russia, 1917-1953
2j america: a nation divided, c1845-1877
The cold war
World war two & the holocaust
World war one
Medieval period: 1066 -1509
The fight for female suffrage
2m wars and welfare: britain in transition, 1906-1957
2d religious conflict and the church in england, c1529-c1570
Britain: 1509 -1745
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08/06/2023
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Inheritance, variation and evolution DNA and chromosomes. • Deoxyribonucleic acid • double helix structure (polymer) Seperated into 46 tight coils called. Chromosomes. • xcx = female C = male xy = Gene = Small Section of ona code for a Sequence of aminoacias-when combined they told to form a protein. Genome = entire set of genetic material in an organism. This allows Scientists to Identity genes that link to genetic diseases Alleles different versions of a gene Homozygous = 2 of the came allele. Heterozygous = 2 different alleles ← one will be dominant and the other recessive genotype = the collection of alleles we have the characteristics you get = phenotype from your genotype. nucleotide • monomer that makes up the ona polymer ·backbone is made of a phosphate and a Sugar • made up of a phosphate, a sugar and a base dna bases. • Adenine 'Thymine: Cytosine complimentry Guanine Complimentary example: A&+CATA T C A G 1 TA genetic code = a Sequence of bases Proteins - a different sequence of amino acids - unique shape allows them to carry out a particular function. - main uses: enzymes hormones Structural protiens Sexual reproduction fusion of male and female gametes • offspring is genetically different to parents. • lots of variation gametes only have 23 chromosomes so that. the cell produced from the fusion will have 46 advantages ・genetic variation ·more resistant to new diseases population can adapt - favorable traits likely to be passed on disadvantages • takes lots of time takes lots of energy requires 2 parents need to find and Impress a mate asexual reproduction only...
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involves one parent so there is no mixing of genetic material offspring are identical Clones. · no variation. mitosis or binary fission advantages · only one parent is needed process is rapid disadvantages no 240 genetic meiosis gametes= Bex cells that have half the genetic. material of a normal cell (haploid) each arm · Cell divides again. variation Suseptible to new diseases less chance of adapting Steps of meiosis · replicate ana • Chromosome pairs line up in the centre • Chromosomes pull apart and cell splits in half A Chromosomes line up in the middle is pulled apart Gregor Mendel founding father of genetics • experimented on pea plants by crossbreeding them together. • found that hereditory units could be recessive ar dominant - his work (koba was enx critisised at the time because DNA had not yet been discovered Recessive = only expressed if the organism. gets the allele from both parents genetic engineering • the process of taking a gene out of an organism with a desirable characteristic and transtering it into another organism so that. it develops the same trait. • the new organism is genetically modified because the organisms genome has been. altered. •this isn't limited to organisms of the same species examples: · Sheep modified to produce drugs in their. mill bacteria modified to produce insulin • Crops modified to be resistant to diseases, insects and herbicides. Gene therapy -giving a person with an inherited disorder the healthy version of their faulty gene - hard to transfer the new gene to every cell. in order to fix the problem. - a solution to this is transtering the gene at the embryo stage of development so that the healthy gene is passed on to other cells transfering genes 1. cut out the desired gene using enzymes 2. Insert into a vector 3. introduce vector to chasen organism 4. Organism will start producing the protein. that the gene codes for animal Cloning 1. take an egg cell from a donor temale and remove the nucleus 2 take an adult body cell from the chosen Organism and remove the nucleus 3. put egg cell 4. Simulate the cell via a small electric shock it will then act as a zygoat and divide this nucleus into the enucleated by mitosis, forming an embryo 3. implant embryo onto the uterus of a Surrogate mother. It will then develop. Cloning transgenic animals to produce human proteins Scientists are now able to put human genes into the ona of other organisms. this means the animal is transgenic Scientists often clone transgenic animals. Cloning by embryo transplants 1. pick a male and female organism with desirable Characteristics 2. take the sperm and fertilise the egg 3. let the zygote develop into an embryo 4. Seperate the embryo into lots of smaller ones 5. put into Surrogate mother 6. Oftspring will be identical Clones Cloning plants - Cuttings 1. Cut off a small part of a plant shoot 2. place cutting in soil with nutrients and hormones. 3. Gutting will grow to be a clone Micro propagation 1. take small pieces of plant tissue from the tips or stems. 2. Sterilise them to remove any microorganism 3. place in agar and allow to grow 4. transfer the calluses into soil where they can grow into plantlets. mutations a mutation is a change in the dna base sequence. This happens spontaneously in our cells when ona is duplicated Carcinogens and radiation increase rish. it a mutation occours, the sequence of amino acide would be different so it would Code for a different protein. y the protein- was an enzyme the mutation may. change the shape of the active site so it cannot bind with the substrate Bubstitution = one base is changed for another random base. Insertion = an extra base is added removed from the deletion = a base is Sequence Inherited disorders = a group of conditions. in alleles and so is inherited passed on From parents polydactyly • babies are born or toes caused by a dominant allele with extra fingers. Cystic fibrosis. Causes sticky mucus to be released in lungs and pancreas Caused by a recessive allell Fossils things left behind by long dead organisms Such as Skeletons, entire organisms that haun't decayed or impressions in ground -Formation: 1. gradual replacement that it is n 2. Casts 3. impressions 4. peservation extinction = no individuals of that species. remain reasons for extinction. - enviroment changes too quickly habitat destruction. introduction of new preditors. human hunting. new diseases catastrophic event antibiotic resistance. 1 bacteria have a mutation that make them less affected by antibiotics 2. resistant bacteria survives and reproduces rapidly - Spreading the gene 3 people pass on resistant bacteria. to others Superbug = bacteria that is resistant to many types of antibiotic Carl linnaeus = linneam system Kingdom → phylum → Class → order → Family & Speciese genus species. Carl wose = three domain System Eukaryota bacteria archaea.