Neurotransmitters and Drugs
Many disorders like Alzheimer's, Parkinson's, schizophrenia, and depression involve problems with neurotransmitters and their receptors. Fortunately, medications can help by acting as agonists or antagonists at synapses.
Agonists are chemicals that bind to and stimulate receptors, mimicking natural neurotransmitters. Antagonists do the opposite - they bind to receptors and block neurotransmitter action. Some drugs work by preventing neurotransmitter breakdown or reuptake, enhancing their effects.
Recreational drugs also act as agonists or antagonists, affecting your brain's reward pathway and altering mood, cognition, perception, and behaviour. This is where things can become problematic.
Drug tolerance develops when agonist drugs overstimulate receptors, causing your nervous system to decrease receptor numbers and sensitivity. You need more drug to get the same effect. Drug addiction occurs with antagonist drugs that block receptors - your nervous system increases receptor numbers, creating cravings.
Important insight: Understanding how drugs affect neurotransmission explains both their therapeutic benefits and their potential for abuse - it's all about how they interfere with your brain's natural chemical communication system.