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AQA GCSE Biology Topic 6: Inheritance, Variation & Evolution Notes

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Ready to dive into the fascinating world of genetics and evolution? This topic covers everything from how your cells create the next generation to why Darwin's ideas revolutionised science - and it's more relevant to your daily life than you might think!
GCSE AQA Biology Triple Topic 6 : Inheritance, Variation and Evolution – page 1

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Reproduction and DNA Basics

Ever wondered how you ended up with your mum's eyes but your dad's nose? It all comes down to meiosis - the special process that creates gametes (sex cells like sperm and eggs). Unlike normal cell division, meiosis creates four genetically different cells, each with half the usual number of chromosomes.

Sexual reproduction needs two parents and creates loads of variation, which helps species survive through natural selection. Asexual reproduction only needs one parent and is much faster - think of how quickly bacteria multiply when you're ill!

Your DNA is basically a twisted ladder (called a double helix) made from four different bases that pair up: C with G, and A with T. Every sequence of three bases codes for one amino acid, and these amino acids link together to make proteins through protein synthesis.

Quick tip: Remember that your genotype is the genetic code you carry, whilst your phenotype is what actually shows up - like having the gene for brown eyes (genotype) and actually having brown eyes (phenotype).

GCSE AQA Biology Triple Topic 6 : Inheritance, Variation and Evolution – page 2

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Genetic Disorders and Natural Selection

Some genetic conditions are caused by dominant alleles (like polydactyly, where you're born with extra fingers), whilst others need recessive alleles from both parents (like cystic fibrosis). This is why Punnett squares are so useful - they help predict what characteristics offspring might inherit.

Evolution happens when populations change over time through natural selection. Here's how it works: individuals show variation, those best suited to their environment survive and reproduce more, and they pass their advantageous alleles to their offspring.

Selective breeding lets humans speed up this process by choosing parents with desirable traits. Farmers use this to create disease-resistant crops or cows that produce more milk. However, it can lead to inbreeding, making organisms more vulnerable to diseases.

Remember: A species is defined as organisms that can reproduce together to produce fertile offspring - which is why horses and donkeys are different species (their offspring, mules, are infertile).

GCSE AQA Biology Triple Topic 6 : Inheritance, Variation and Evolution – page 3

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Genetic Engineering and Cloning

Genetic engineering sounds like science fiction, but it's happening right now! Scientists can take genes from one organism and put them into another to create desired characteristics. For example, bacteria can be modified to produce human insulin for diabetics.

The process involves using restriction enzymes to cut out specific genes, inserting them into plasmids (tiny DNA circles in bacteria), then using ligase to seal everything together. The modified bacteria then multiply, creating loads of the desired product.

Cloning comes in several forms. Tissue culture and cuttings help preserve rare plants, whilst embryo transplants split early animal embryos before cells specialise. Adult cell cloning is the most complex - scientists remove the nucleus from an unfertilised egg and replace it with a nucleus from an adult cell.

Fascinating fact: Dolly the sheep was created using adult cell cloning, proving that even specialised adult cells contain all the genetic information needed to create a whole organism!

GCSE AQA Biology Triple Topic 6 : Inheritance, Variation and Evolution – page 4

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Evolution Scientists and Fossils

Charles Darwin changed everything with his theory of evolution by natural selection, published in "On the Origin of Species". His ideas took time to be accepted because they challenged religious beliefs, lacked sufficient evidence, and scientists didn't yet understand how inheritance worked.

Speciation occurs when populations become geographically separated and face different environmental pressures. Over time, mutations and natural selection cause so many changes that the groups can no longer interbreed - creating new species.

Gregor Mendel discovered the basic principles of inheritance through his plant breeding experiments, showing that characteristics are passed down in distinct "units" (what we now call genes). Fossils provide evidence of evolution, forming when organisms don't fully decay, when minerals replace bones, or when traces like footprints are preserved.

Key point: The fossil record is incomplete because most early organisms were soft-bodied, geological activity destroyed many fossils, and fossilisation requires very specific conditions.

GCSE AQA Biology Triple Topic 6 : Inheritance, Variation and Evolution – page 5

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Disease Resistance and Classification

Antibiotics only work against bacteria because they target bacterial cell walls - but viruses don't have cell walls, which is why antibiotics can't cure viral infections like colds. Unfortunately, antibiotic resistance is becoming a major problem as bacterial mutations create strains that survive antibiotic treatment.

MRSA is a dangerous example of antibiotic-resistant bacteria. To slow the development of resistance, doctors shouldn't prescribe antibiotics for minor infections, patients must complete their full course, and agricultural antibiotic use should be limited.

Scientists classify living things using the Linnaean system: Kingdom, Phylum, Class, Order, Family, Genus, Species. This helps us understand relationships between organisms and gives scientists a common language. Carl Woese later proposed the three-domain system, dividing life into Archaea (primitive bacteria in extreme environments), Bacteria (true bacteria), and Eukaryota (everything else with proper cell nuclei).

Study tip: Remember the classification order with "King Philip Came Over For Good Soup" - it's a classic memory trick that actually works!

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