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19 Dec 2025

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AQA GCSE Biology Topic 6: Inheritance, Variation & Evolution Notes

H

heather @heatherwu

Ready to dive into the fascinating world of genetics and evolution? This topic covers everything from how your... Show more

Meiosis
→ leads to non identical cells
creates gametes (sex cells)

Process:
1. Copies of genetic information are made
2. Cell divides twice

Reproduction and DNA Basics

Ever wondered how you ended up with your mum's eyes but your dad's nose? It all comes down to meiosis - the special process that creates gametes (sex cells like sperm and eggs). Unlike normal cell division, meiosis creates four genetically different cells, each with half the usual number of chromosomes.

Sexual reproduction needs two parents and creates loads of variation, which helps species survive through natural selection. Asexual reproduction only needs one parent and is much faster - think of how quickly bacteria multiply when you're ill!

Your DNA is basically a twisted ladder (called a double helix) made from four different bases that pair up C with G, and A with T. Every sequence of three bases codes for one amino acid, and these amino acids link together to make proteins through protein synthesis.

Quick tip Remember that your genotype is the genetic code you carry, whilst your phenotype is what actually shows up - like having the gene for brown eyes (genotype) and actually having brown eyes (phenotype).

Meiosis
→ leads to non identical cells
creates gametes (sex cells)

Process:
1. Copies of genetic information are made
2. Cell divides twice

Genetic Disorders and Natural Selection

Some genetic conditions are caused by dominant alleles (like polydactyly, where you're born with extra fingers), whilst others need recessive alleles from both parents (like cystic fibrosis). This is why Punnett squares are so useful - they help predict what characteristics offspring might inherit.

Evolution happens when populations change over time through natural selection. Here's how it works individuals show variation, those best suited to their environment survive and reproduce more, and they pass their advantageous alleles to their offspring.

Selective breeding lets humans speed up this process by choosing parents with desirable traits. Farmers use this to create disease-resistant crops or cows that produce more milk. However, it can lead to inbreeding, making organisms more vulnerable to diseases.

Remember A species is defined as organisms that can reproduce together to produce fertile offspring - which is why horses and donkeys are different species (their offspring, mules, are infertile).

Meiosis
→ leads to non identical cells
creates gametes (sex cells)

Process:
1. Copies of genetic information are made
2. Cell divides twice

Genetic Engineering and Cloning

Genetic engineering sounds like science fiction, but it's happening right now! Scientists can take genes from one organism and put them into another to create desired characteristics. For example, bacteria can be modified to produce human insulin for diabetics.

The process involves using restriction enzymes to cut out specific genes, inserting them into plasmids (tiny DNA circles in bacteria), then using ligase to seal everything together. The modified bacteria then multiply, creating loads of the desired product.

Cloning comes in several forms. Tissue culture and cuttings help preserve rare plants, whilst embryo transplants split early animal embryos before cells specialise. Adult cell cloning is the most complex - scientists remove the nucleus from an unfertilised egg and replace it with a nucleus from an adult cell.

Fascinating fact Dolly the sheep was created using adult cell cloning, proving that even specialised adult cells contain all the genetic information needed to create a whole organism!

Meiosis
→ leads to non identical cells
creates gametes (sex cells)

Process:
1. Copies of genetic information are made
2. Cell divides twice

Evolution Scientists and Fossils

Charles Darwin changed everything with his theory of evolution by natural selection, published in "On the Origin of Species". His ideas took time to be accepted because they challenged religious beliefs, lacked sufficient evidence, and scientists didn't yet understand how inheritance worked.

Speciation occurs when populations become geographically separated and face different environmental pressures. Over time, mutations and natural selection cause so many changes that the groups can no longer interbreed - creating new species.

Gregor Mendel discovered the basic principles of inheritance through his plant breeding experiments, showing that characteristics are passed down in distinct "units" (what we now call genes). Fossils provide evidence of evolution, forming when organisms don't fully decay, when minerals replace bones, or when traces like footprints are preserved.

Key point The fossil record is incomplete because most early organisms were soft-bodied, geological activity destroyed many fossils, and fossilisation requires very specific conditions.

Meiosis
→ leads to non identical cells
creates gametes (sex cells)

Process:
1. Copies of genetic information are made
2. Cell divides twice

Disease Resistance and Classification

Antibiotics only work against bacteria because they target bacterial cell walls - but viruses don't have cell walls, which is why antibiotics can't cure viral infections like colds. Unfortunately, antibiotic resistance is becoming a major problem as bacterial mutations create strains that survive antibiotic treatment.

MRSA is a dangerous example of antibiotic-resistant bacteria. To slow the development of resistance, doctors shouldn't prescribe antibiotics for minor infections, patients must complete their full course, and agricultural antibiotic use should be limited.

Scientists classify living things using the Linnaean system Kingdom, Phylum, Class, Order, Family, Genus, Species. This helps us understand relationships between organisms and gives scientists a common language. Carl Woese later proposed the three-domain system, dividing life into Archaea (primitive bacteria in extreme environments), Bacteria (true bacteria), and Eukaryota (everything else with proper cell nuclei).

Study tip Remember the classification order with "King Philip Came Over For Good Soup" - it's a classic memory trick that actually works!

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very reliable app to help and grow your ideas of Maths, English and other related topics in your works. please use this app if your struggling in areas, this app is key for that. wish I'd of done a review before. and it's also free so don't worry about that.

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Elisha

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This apps acc the goat. I find revision so boring but this app makes it so easy to organize it all and then you can ask the freeeee ai to test yourself so good and you can easily upload your own stuff. highly recommend as someone taking mocks now

Paul T

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The app is very easy to use and well designed. I have found everything I was looking for so far and have been able to learn a lot from the presentations! I will definitely use the app for a class assignment! And of course it also helps a lot as an inspiration.

Stefan S

iOS user

This app is really great. There are so many study notes and help [...]. My problem subject is French, for example, and the app has so many options for help. Thanks to this app, I have improved my French. I would recommend it to anyone.

Samantha Klich

Android user

Wow, I am really amazed. I just tried the app because I've seen it advertised many times and was absolutely stunned. This app is THE HELP you want for school and above all, it offers so many things, such as workouts and fact sheets, which have been VERY helpful to me personally.

Anna

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Best app on earth! no words because it’s too good

Thomas R

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Just amazing. Let's me revise 10x better, this app is a quick 10/10. I highly recommend it to anyone. I can watch and search for notes. I can save them in the subject folder. I can revise it any time when I come back. If you haven't tried this app, you're really missing out.

Basil

Android user

This app has made me feel so much more confident in my exam prep, not only through boosting my own self confidence through the features that allow you to connect with others and feel less alone, but also through the way the app itself is centred around making you feel better. It is easy to navigate, fun to use, and helpful to anyone struggling in absolutely any way.

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Xander S

iOS user

THE QUIZES AND FLASHCARDS ARE SO USEFUL AND I LOVE THE SCHOOLGPT. IT ALSO IS LITREALLY LIKE CHATGPT BUT SMARTER!! HELPED ME WITH MY MASCARA PROBLEMS TOO!! AS WELL AS MY REAL SUBJECTS ! DUHHH 😍😁😲🤑💗✨🎀😮

Elisha

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Paul T

iOS user

 

Biology

280

19 Dec 2025

5 pages

AQA GCSE Biology Topic 6: Inheritance, Variation & Evolution Notes

H

heather

@heatherwu

Ready to dive into the fascinating world of genetics and evolution? This topic covers everything from how your cells create the next generation to why Darwin's ideas revolutionised science - and it's more relevant to your daily life than you... Show more

Meiosis
→ leads to non identical cells
creates gametes (sex cells)

Process:
1. Copies of genetic information are made
2. Cell divides twice

Sign up to see the contentIt's free!

Access to all documents

Improve your grades

Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Reproduction and DNA Basics

Ever wondered how you ended up with your mum's eyes but your dad's nose? It all comes down to meiosis - the special process that creates gametes (sex cells like sperm and eggs). Unlike normal cell division, meiosis creates four genetically different cells, each with half the usual number of chromosomes.

Sexual reproduction needs two parents and creates loads of variation, which helps species survive through natural selection. Asexual reproduction only needs one parent and is much faster - think of how quickly bacteria multiply when you're ill!

Your DNA is basically a twisted ladder (called a double helix) made from four different bases that pair up: C with G, and A with T. Every sequence of three bases codes for one amino acid, and these amino acids link together to make proteins through protein synthesis.

Quick tip: Remember that your genotype is the genetic code you carry, whilst your phenotype is what actually shows up - like having the gene for brown eyes (genotype) and actually having brown eyes (phenotype).

Meiosis
→ leads to non identical cells
creates gametes (sex cells)

Process:
1. Copies of genetic information are made
2. Cell divides twice

Sign up to see the contentIt's free!

Access to all documents

Improve your grades

Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Genetic Disorders and Natural Selection

Some genetic conditions are caused by dominant alleles (like polydactyly, where you're born with extra fingers), whilst others need recessive alleles from both parents (like cystic fibrosis). This is why Punnett squares are so useful - they help predict what characteristics offspring might inherit.

Evolution happens when populations change over time through natural selection. Here's how it works: individuals show variation, those best suited to their environment survive and reproduce more, and they pass their advantageous alleles to their offspring.

Selective breeding lets humans speed up this process by choosing parents with desirable traits. Farmers use this to create disease-resistant crops or cows that produce more milk. However, it can lead to inbreeding, making organisms more vulnerable to diseases.

Remember: A species is defined as organisms that can reproduce together to produce fertile offspring - which is why horses and donkeys are different species (their offspring, mules, are infertile).

Meiosis
→ leads to non identical cells
creates gametes (sex cells)

Process:
1. Copies of genetic information are made
2. Cell divides twice

Sign up to see the contentIt's free!

Access to all documents

Improve your grades

Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Genetic Engineering and Cloning

Genetic engineering sounds like science fiction, but it's happening right now! Scientists can take genes from one organism and put them into another to create desired characteristics. For example, bacteria can be modified to produce human insulin for diabetics.

The process involves using restriction enzymes to cut out specific genes, inserting them into plasmids (tiny DNA circles in bacteria), then using ligase to seal everything together. The modified bacteria then multiply, creating loads of the desired product.

Cloning comes in several forms. Tissue culture and cuttings help preserve rare plants, whilst embryo transplants split early animal embryos before cells specialise. Adult cell cloning is the most complex - scientists remove the nucleus from an unfertilised egg and replace it with a nucleus from an adult cell.

Fascinating fact: Dolly the sheep was created using adult cell cloning, proving that even specialised adult cells contain all the genetic information needed to create a whole organism!

Meiosis
→ leads to non identical cells
creates gametes (sex cells)

Process:
1. Copies of genetic information are made
2. Cell divides twice

Sign up to see the contentIt's free!

Access to all documents

Improve your grades

Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Evolution Scientists and Fossils

Charles Darwin changed everything with his theory of evolution by natural selection, published in "On the Origin of Species". His ideas took time to be accepted because they challenged religious beliefs, lacked sufficient evidence, and scientists didn't yet understand how inheritance worked.

Speciation occurs when populations become geographically separated and face different environmental pressures. Over time, mutations and natural selection cause so many changes that the groups can no longer interbreed - creating new species.

Gregor Mendel discovered the basic principles of inheritance through his plant breeding experiments, showing that characteristics are passed down in distinct "units" (what we now call genes). Fossils provide evidence of evolution, forming when organisms don't fully decay, when minerals replace bones, or when traces like footprints are preserved.

Key point: The fossil record is incomplete because most early organisms were soft-bodied, geological activity destroyed many fossils, and fossilisation requires very specific conditions.

Meiosis
→ leads to non identical cells
creates gametes (sex cells)

Process:
1. Copies of genetic information are made
2. Cell divides twice

Sign up to see the contentIt's free!

Access to all documents

Improve your grades

Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Disease Resistance and Classification

Antibiotics only work against bacteria because they target bacterial cell walls - but viruses don't have cell walls, which is why antibiotics can't cure viral infections like colds. Unfortunately, antibiotic resistance is becoming a major problem as bacterial mutations create strains that survive antibiotic treatment.

MRSA is a dangerous example of antibiotic-resistant bacteria. To slow the development of resistance, doctors shouldn't prescribe antibiotics for minor infections, patients must complete their full course, and agricultural antibiotic use should be limited.

Scientists classify living things using the Linnaean system: Kingdom, Phylum, Class, Order, Family, Genus, Species. This helps us understand relationships between organisms and gives scientists a common language. Carl Woese later proposed the three-domain system, dividing life into Archaea (primitive bacteria in extreme environments), Bacteria (true bacteria), and Eukaryota (everything else with proper cell nuclei).

Study tip: Remember the classification order with "King Philip Came Over For Good Soup" - it's a classic memory trick that actually works!

We thought you’d never ask...

What is the Knowunity AI companion?

Our AI Companion is a student-focused AI tool that offers more than just answers. Built on millions of Knowunity resources, it provides relevant information, personalised study plans, quizzes, and content directly in the chat, adapting to your individual learning journey.

Where can I download the Knowunity app?

You can download the app from Google Play Store and Apple App Store.

Is Knowunity really free of charge?

That's right! Enjoy free access to study content, connect with fellow students, and get instant help – all at your fingertips.

5

Smart Tools NEW

Transform this note into: ✓ 50+ Practice Questions ✓ Interactive Flashcards ✓ Full Mock Exam ✓ Essay Outlines

Mock Exam
Quiz
Flashcards
Essay

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Natural Selection & GMOs

Explore the principles of natural selection, genetic variation, and genetic modification in this comprehensive study note. Covering key concepts such as recombinant DNA, selective breeding, and the classification of species, this resource is essential for GCSE Edexcel Biology students. Understand how evolution shapes biodiversity and the role of biotechnology in agriculture and medicine.

BiologyBiology
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Evolution and Variation Insights

Explore key concepts of evolution and variation in this comprehensive study resource. Covering essential topics such as natural selection, genetic engineering, and the fossil record, this 9-page revision guide includes exam-style questions and answers to enhance your understanding. Perfect for AQA GCSE Biology students seeking to master the principles of evolution and genetic variation.

BiologyBiology
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BiologyBiology
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Explore the fundamentals of selective breeding, including its definition, detailed process, advantages such as improved yield and desirable traits, and disadvantages like inbreeding and health issues. This summary provides essential insights for students studying genetics and agriculture.

BiologyBiology
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Genetics and Evolution Insights

Explore key concepts in genetics, inheritance, and evolution with this comprehensive summary. Understand selective breeding, cloning, genetic engineering, and the impact of mutations on species. Ideal for GCSE Biology AQA students, this resource covers essential topics like natural selection, genetic variation, and the Linnaean classification system.

BiologyBiology
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Most popular content: Genetic Variation

Most popular content in Biology

Most popular content

Can't find what you're looking for? Explore other subjects.

Students love us — and so will you.

4.9/5

App Store

4.8/5

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The app is very easy to use and well designed. I have found everything I was looking for so far and have been able to learn a lot from the presentations! I will definitely use the app for a class assignment! And of course it also helps a lot as an inspiration.

Stefan S

iOS user

This app is really great. There are so many study notes and help [...]. My problem subject is French, for example, and the app has so many options for help. Thanks to this app, I have improved my French. I would recommend it to anyone.

Samantha Klich

Android user

Wow, I am really amazed. I just tried the app because I've seen it advertised many times and was absolutely stunned. This app is THE HELP you want for school and above all, it offers so many things, such as workouts and fact sheets, which have been VERY helpful to me personally.

Anna

iOS user

Best app on earth! no words because it’s too good

Thomas R

iOS user

Just amazing. Let's me revise 10x better, this app is a quick 10/10. I highly recommend it to anyone. I can watch and search for notes. I can save them in the subject folder. I can revise it any time when I come back. If you haven't tried this app, you're really missing out.

Basil

Android user

This app has made me feel so much more confident in my exam prep, not only through boosting my own self confidence through the features that allow you to connect with others and feel less alone, but also through the way the app itself is centred around making you feel better. It is easy to navigate, fun to use, and helpful to anyone struggling in absolutely any way.

David K

iOS user

The app's just great! All I have to do is enter the topic in the search bar and I get the response real fast. I don't have to watch 10 YouTube videos to understand something, so I'm saving my time. Highly recommended!

Sudenaz Ocak

Android user

In school I was really bad at maths but thanks to the app, I am doing better now. I am so grateful that you made the app.

Greenlight Bonnie

Android user

very reliable app to help and grow your ideas of Maths, English and other related topics in your works. please use this app if your struggling in areas, this app is key for that. wish I'd of done a review before. and it's also free so don't worry about that.

Rohan U

Android user

I know a lot of apps use fake accounts to boost their reviews but this app deserves it all. Originally I was getting 4 in my English exams and this time I got a grade 7. I didn’t even know about this app three days until the exam and it has helped A LOT. Please actually trust me and use it as I’m sure you too will see developments.

Xander S

iOS user

THE QUIZES AND FLASHCARDS ARE SO USEFUL AND I LOVE THE SCHOOLGPT. IT ALSO IS LITREALLY LIKE CHATGPT BUT SMARTER!! HELPED ME WITH MY MASCARA PROBLEMS TOO!! AS WELL AS MY REAL SUBJECTS ! DUHHH 😍😁😲🤑💗✨🎀😮

Elisha

iOS user

This apps acc the goat. I find revision so boring but this app makes it so easy to organize it all and then you can ask the freeeee ai to test yourself so good and you can easily upload your own stuff. highly recommend as someone taking mocks now

Paul T

iOS user

The app is very easy to use and well designed. I have found everything I was looking for so far and have been able to learn a lot from the presentations! I will definitely use the app for a class assignment! And of course it also helps a lot as an inspiration.

Stefan S

iOS user

This app is really great. There are so many study notes and help [...]. My problem subject is French, for example, and the app has so many options for help. Thanks to this app, I have improved my French. I would recommend it to anyone.

Samantha Klich

Android user

Wow, I am really amazed. I just tried the app because I've seen it advertised many times and was absolutely stunned. This app is THE HELP you want for school and above all, it offers so many things, such as workouts and fact sheets, which have been VERY helpful to me personally.

Anna

iOS user

Best app on earth! no words because it’s too good

Thomas R

iOS user

Just amazing. Let's me revise 10x better, this app is a quick 10/10. I highly recommend it to anyone. I can watch and search for notes. I can save them in the subject folder. I can revise it any time when I come back. If you haven't tried this app, you're really missing out.

Basil

Android user

This app has made me feel so much more confident in my exam prep, not only through boosting my own self confidence through the features that allow you to connect with others and feel less alone, but also through the way the app itself is centred around making you feel better. It is easy to navigate, fun to use, and helpful to anyone struggling in absolutely any way.

David K

iOS user

The app's just great! All I have to do is enter the topic in the search bar and I get the response real fast. I don't have to watch 10 YouTube videos to understand something, so I'm saving my time. Highly recommended!

Sudenaz Ocak

Android user

In school I was really bad at maths but thanks to the app, I am doing better now. I am so grateful that you made the app.

Greenlight Bonnie

Android user

very reliable app to help and grow your ideas of Maths, English and other related topics in your works. please use this app if your struggling in areas, this app is key for that. wish I'd of done a review before. and it's also free so don't worry about that.

Rohan U

Android user

I know a lot of apps use fake accounts to boost their reviews but this app deserves it all. Originally I was getting 4 in my English exams and this time I got a grade 7. I didn’t even know about this app three days until the exam and it has helped A LOT. Please actually trust me and use it as I’m sure you too will see developments.

Xander S

iOS user

THE QUIZES AND FLASHCARDS ARE SO USEFUL AND I LOVE THE SCHOOLGPT. IT ALSO IS LITREALLY LIKE CHATGPT BUT SMARTER!! HELPED ME WITH MY MASCARA PROBLEMS TOO!! AS WELL AS MY REAL SUBJECTS ! DUHHH 😍😁😲🤑💗✨🎀😮

Elisha

iOS user

This apps acc the goat. I find revision so boring but this app makes it so easy to organize it all and then you can ask the freeeee ai to test yourself so good and you can easily upload your own stuff. highly recommend as someone taking mocks now

Paul T

iOS user