Cellular Control
Genetic mutations happen when DNA gets copied incorrectly during replication, but don't panic - most mutations don't actually change anything! This is because loads of your DNA doesn't code for proteins anyway, and the genetic code is degenerate (multiple combinations can code for the same amino acid).
Mutagens like X-rays, UV light, and even alcohol increase your chances of getting mutations. The scary bit? Some mutations involve nucleotide repeats that get worse through generations - like in Huntington's Disease where too many CAG repeats create proteins that can't fold properly.
Your cells are incredibly smart at gene regulation though. They control genes at three levels: whether DNA gets transcribed to mRNA, whether mRNA gets translated to proteins, and whether those proteins actually work. Think of it like having multiple security checkpoints!
The lac operon in bacteria is a brilliant example of this control. When lactose is around, it switches on genes to make enzymes that break down lactose. No lactose? The genes stay switched off. It's like your cells have their own on/off switches.
Key insight: Your DNA code is universal (all life uses it), degenerate built−inbackupsystem, and works in triplets - making it incredibly robust against mutations.
Transcription factors are the master controllers - proteins that decide which genes get switched on or off by binding to specific DNA regions. They're like molecular switches that help your cells respond to what's happening around them.