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BiologyBiology424 views·Updated 23 Jun 2026·16 pages

GCSE Biology: Cells and Microscopy - AQA Combined Science Notes

user profile picture
issy@issy_chap

Your body is made up of trillions of tiny building...

1
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

Cell Types and Basic Structure

Every living thing on Earth is built from cells, but not all cells are the same. Eukaryotic cells (found in animals, plants, and fungi) are the complex type with a nucleus that acts like a control centre. Prokaryotic cells (bacteria) are much simpler and don't have this nucleus - their genetic material just floats around freely.

Think of it like comparing a modern office building (eukaryotic) with a simple workshop (prokaryotic). Both get the job done, but one is much more organised and compartmentalised.

Animal cells contain the basics: a nucleus, cell membrane, cytoplasm, mitochondria, and ribosomes. Plant cells have all of these plus some extras like a cell wall, chloroplasts, and a permanent vacuole that help them survive as stationary organisms that make their own food.

Quick Tip: Remember that plant cells have everything animal cells have, plus three extra structures - they're basically animal cells with a plant upgrade pack!

2
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

Cell Component Functions

Each part of a cell has a specific job, just like rooms in a house. The nucleus is like the head office - it controls everything and stores all the DNA (genetic instructions). The cell membrane acts as a selective bouncer, deciding what gets in and what stays out of the cell.

Cytoplasm is the jelly-like substance where most chemical reactions happen - think of it as the cell's workshop floor. Ribosomes are tiny protein-making factories, whilst mitochondria are the cell's power stations, breaking down glucose to release energy through aerobic respiration.

The cell membrane being partially permeable is crucial - it means the cell can control its environment by letting useful substances in whilst keeping harmful ones out. This selective barrier keeps the cell functioning properly.

Key Concept: Every cell structure relates to its function - if you understand what a cell needs to do, you can work out why it has certain parts!

3
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

Plant-Specific Structures and Chromosomes

Plant cells need extra kit to survive as stationary, food-making organisms. Chloroplasts contain chlorophyll (the green pigment) and are where photosynthesis happens - basically solar panels that convert sunlight into food. The permanent vacuole keeps plant cells firm and upright, like an internal water balloon providing structure.

Chromosomes are where your genetic information lives - think of them as instruction manuals made of DNA. Humans have 46 chromosomes arranged in 23 pairs, and each chromosome contains hundreds of genes (individual instructions for specific traits).

During most of the cell's life, chromosomes are too thin to see under a microscope. They only become visible when the cell is dividing, at which point they thicken up like rope being coiled.

Memory Trick: Plants are green because of chloroplasts, and they stay upright because of their permanent vacuole - no skeleton needed!

4
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

Bacterial Cells and Key Differences

Bacterial cells are the minimalists of the cell world - they have just the essentials. Instead of a nucleus, they have a DNA loop floating freely in the cytoplasm. Plasmids are like bonus DNA circles that often carry useful genes, such as antibiotic resistance, and bacteria can share these between themselves.

Many bacteria have a flagellum - a whip-like tail that spins like a propeller to help them swim around. This gives them mobility that plant and animal cells don't have.

The main differences are size and organisation. Prokaryotic cells are about 10 times smaller than eukaryotic cells and much simpler. Think of eukaryotes as having filing cabinets (nucleus) for their paperwork, whilst prokaryotes just have everything scattered on the desk.

Real-World Connection: Understanding plasmids is crucial for modern medicine - antibiotic resistance spreads when bacteria share plasmids containing resistance genes!

5
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

Cell Comparison and Size Scale

This comparison table shows you exactly what each cell type contains - it's perfect for exam revision. Notice that bacterial cells are missing some key organelles like mitochondria (they do respiration differently) and obviously don't have plant-specific structures.

Understanding unit conversions is essential when studying cells. Moving from millimetres (mm) to micrometres (μm) to nanometres (nm), each step involves multiplying or dividing by 1000. Most eukaryotic cells measure 10-100 μm, whilst prokaryotic cells are typically 1-10 μm.

To put this in perspective, a typical animal cell is about 30 μm across - that means roughly 33 cells could fit across the width of a millimetre. No wonder we need microscopes to see them properly!

Exam Tip: Learn these size ranges - questions often ask you to identify cell types based on their dimensions or to convert between units!

6
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

Cell Specialisation Process

Cell differentiation is how generic cells become specialists with specific jobs - it's like students choosing their career paths. All animal cells start as stem cells in early development, which are basically blank slates with the potential to become any cell type the body needs.

In animals, most cells choose their specialisation early and stick with it. Once you're a heart cell, you're a heart cell for life. This is why cell division in mature animals mainly happens for repair and replacement rather than growth.

The process starts with fertilisation creating a zygote, which divides through mitosis to form an embryo. As the embryo develops, different cells receive different chemical signals that switch on specific genes, leading to specialisation.

Think About It: Your body contains over 200 different cell types, all derived from that single fertilised egg - that's the power of differentiation!

7
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

Plant vs Animal Differentiation and Specialised Cells

Unlike animals, plants keep their options open. Many plant cells can differentiate throughout the plant's entire life, especially those in meristems (growing regions). This flexibility helps plants adapt to changing conditions and keeps them growing.

Red blood cells are perfectly designed oxygen taxis - their biconcave disc shape maximises surface area for oxygen absorption, and they've ditched their nucleus to make room for more haemoglobin theoxygencarryingproteinthe oxygen-carrying protein. They're basically mobile oxygen sponges.

Muscle cells are power-packed with mitochondria because contraction requires massive amounts of energy. Think of them as athletes who need extra energy drinks to perform.

Cool Fact: Red blood cells live for about 120 days and travel roughly 480 kilometres through your circulatory system during their lifetime!

8
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

More Specialised Animal and Plant Cells

Nerve cells are the body's electrical cables, with long axons that can stretch over a metre in tall people. The myelin sheath acts like insulation on electrical wire, speeding up nerve impulses to keep your reflexes sharp.

Sperm cells are swimming missiles designed for one purpose. The acrosome contains enzymes to break through the egg's defences, the middle section is packed with mitochondria for energy, and the tail provides propulsion. They're basically biological torpedoes.

Palisade cells in plant leaves are solar panel specialists, crammed full of chloroplasts to maximise photosynthesis. They're positioned at the top of leaves to catch the most sunlight possible.

Amazing Fact: A single sperm cell can swim up to 25 cm per hour - that might sound slow, but for something microscopic, it's incredibly fast!

9
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

Plant Transport and Root Cells

Root hair cells are like tiny straws with massive surface area thanks to their finger-like projections. They're packed with mitochondria to power the active transport of mineral ions against concentration gradients - basically pumping nutrients uphill.

Xylem cells are nature's plumbing system. These dead, hollow tubes transport water and minerals from roots to leaves. Their walls are strengthened with lignin (the stuff that makes wood hard), creating sturdy pipes that can handle the pressure.

Phloem cells are the food delivery service, transporting sugars made during photosynthesis to wherever the plant needs energy. They're living cells with perforated end walls and minimal internal structures to maximise flow space.

Plant Engineering: Xylem and phloem together form vascular bundles - think of them as the plant's circulatory system, with xylem as arteries and phloem as veins!

10
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

Microscopy and Magnification

Magnification tells you how much bigger the image is compared to the real object - if something appears 10 times larger than actual size, it's magnified 10×. Resolution is about detail - it's the smallest distance between two points that can still be seen as separate.

Using a light microscope properly requires a systematic approach: start with low power to locate your specimen, then gradually increase magnification whilst fine-tuning the focus. Rushing to high power first usually means you'll lose your specimen entirely.

Total magnification is calculated by multiplying the eyepiece lens magnification by the objective lens magnification. If your eyepiece is 10× and your objective is 40×, your total magnification is 400×.

Practical Tip: Always start with the lowest power objective lens and work your way up - this prevents you from crashing the lens into your slide and gives you the best chance of finding interesting specimens!

We thought you’d never ask...

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BiologyBiology424 views·Updated 23 Jun 2026·16 pages

GCSE Biology: Cells and Microscopy - AQA Combined Science Notes

user profile picture
issy@issy_chap

Your body is made up of trillions of tiny building blocks called cells - and understanding them is key to getting biology! This topic covers everything from the basic structures that keep you alive to how scientists use microscopes to...

1
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

Sign up to see the content. It's free!

  • Access to all documents
  • Improve your grades
  • Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Cell Types and Basic Structure

Every living thing on Earth is built from cells, but not all cells are the same. Eukaryotic cells (found in animals, plants, and fungi) are the complex type with a nucleus that acts like a control centre. Prokaryotic cells (bacteria) are much simpler and don't have this nucleus - their genetic material just floats around freely.

Think of it like comparing a modern office building (eukaryotic) with a simple workshop (prokaryotic). Both get the job done, but one is much more organised and compartmentalised.

Animal cells contain the basics: a nucleus, cell membrane, cytoplasm, mitochondria, and ribosomes. Plant cells have all of these plus some extras like a cell wall, chloroplasts, and a permanent vacuole that help them survive as stationary organisms that make their own food.

Quick Tip: Remember that plant cells have everything animal cells have, plus three extra structures - they're basically animal cells with a plant upgrade pack!

2
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

Sign up to see the content. It's free!

  • Access to all documents
  • Improve your grades
  • Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Cell Component Functions

Each part of a cell has a specific job, just like rooms in a house. The nucleus is like the head office - it controls everything and stores all the DNA (genetic instructions). The cell membrane acts as a selective bouncer, deciding what gets in and what stays out of the cell.

Cytoplasm is the jelly-like substance where most chemical reactions happen - think of it as the cell's workshop floor. Ribosomes are tiny protein-making factories, whilst mitochondria are the cell's power stations, breaking down glucose to release energy through aerobic respiration.

The cell membrane being partially permeable is crucial - it means the cell can control its environment by letting useful substances in whilst keeping harmful ones out. This selective barrier keeps the cell functioning properly.

Key Concept: Every cell structure relates to its function - if you understand what a cell needs to do, you can work out why it has certain parts!

3
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

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  • Access to all documents
  • Improve your grades
  • Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Plant-Specific Structures and Chromosomes

Plant cells need extra kit to survive as stationary, food-making organisms. Chloroplasts contain chlorophyll (the green pigment) and are where photosynthesis happens - basically solar panels that convert sunlight into food. The permanent vacuole keeps plant cells firm and upright, like an internal water balloon providing structure.

Chromosomes are where your genetic information lives - think of them as instruction manuals made of DNA. Humans have 46 chromosomes arranged in 23 pairs, and each chromosome contains hundreds of genes (individual instructions for specific traits).

During most of the cell's life, chromosomes are too thin to see under a microscope. They only become visible when the cell is dividing, at which point they thicken up like rope being coiled.

Memory Trick: Plants are green because of chloroplasts, and they stay upright because of their permanent vacuole - no skeleton needed!

4
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

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  • Access to all documents
  • Improve your grades
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By signing up you accept Terms of Service and Privacy Policy

Bacterial Cells and Key Differences

Bacterial cells are the minimalists of the cell world - they have just the essentials. Instead of a nucleus, they have a DNA loop floating freely in the cytoplasm. Plasmids are like bonus DNA circles that often carry useful genes, such as antibiotic resistance, and bacteria can share these between themselves.

Many bacteria have a flagellum - a whip-like tail that spins like a propeller to help them swim around. This gives them mobility that plant and animal cells don't have.

The main differences are size and organisation. Prokaryotic cells are about 10 times smaller than eukaryotic cells and much simpler. Think of eukaryotes as having filing cabinets (nucleus) for their paperwork, whilst prokaryotes just have everything scattered on the desk.

Real-World Connection: Understanding plasmids is crucial for modern medicine - antibiotic resistance spreads when bacteria share plasmids containing resistance genes!

5
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

Sign up to see the content. It's free!

  • Access to all documents
  • Improve your grades
  • Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Cell Comparison and Size Scale

This comparison table shows you exactly what each cell type contains - it's perfect for exam revision. Notice that bacterial cells are missing some key organelles like mitochondria (they do respiration differently) and obviously don't have plant-specific structures.

Understanding unit conversions is essential when studying cells. Moving from millimetres (mm) to micrometres (μm) to nanometres (nm), each step involves multiplying or dividing by 1000. Most eukaryotic cells measure 10-100 μm, whilst prokaryotic cells are typically 1-10 μm.

To put this in perspective, a typical animal cell is about 30 μm across - that means roughly 33 cells could fit across the width of a millimetre. No wonder we need microscopes to see them properly!

Exam Tip: Learn these size ranges - questions often ask you to identify cell types based on their dimensions or to convert between units!

6
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

Sign up to see the content. It's free!

  • Access to all documents
  • Improve your grades
  • Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Cell Specialisation Process

Cell differentiation is how generic cells become specialists with specific jobs - it's like students choosing their career paths. All animal cells start as stem cells in early development, which are basically blank slates with the potential to become any cell type the body needs.

In animals, most cells choose their specialisation early and stick with it. Once you're a heart cell, you're a heart cell for life. This is why cell division in mature animals mainly happens for repair and replacement rather than growth.

The process starts with fertilisation creating a zygote, which divides through mitosis to form an embryo. As the embryo develops, different cells receive different chemical signals that switch on specific genes, leading to specialisation.

Think About It: Your body contains over 200 different cell types, all derived from that single fertilised egg - that's the power of differentiation!

7
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

Sign up to see the content. It's free!

  • Access to all documents
  • Improve your grades
  • Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Plant vs Animal Differentiation and Specialised Cells

Unlike animals, plants keep their options open. Many plant cells can differentiate throughout the plant's entire life, especially those in meristems (growing regions). This flexibility helps plants adapt to changing conditions and keeps them growing.

Red blood cells are perfectly designed oxygen taxis - their biconcave disc shape maximises surface area for oxygen absorption, and they've ditched their nucleus to make room for more haemoglobin theoxygencarryingproteinthe oxygen-carrying protein. They're basically mobile oxygen sponges.

Muscle cells are power-packed with mitochondria because contraction requires massive amounts of energy. Think of them as athletes who need extra energy drinks to perform.

Cool Fact: Red blood cells live for about 120 days and travel roughly 480 kilometres through your circulatory system during their lifetime!

8
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

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  • Access to all documents
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By signing up you accept Terms of Service and Privacy Policy

More Specialised Animal and Plant Cells

Nerve cells are the body's electrical cables, with long axons that can stretch over a metre in tall people. The myelin sheath acts like insulation on electrical wire, speeding up nerve impulses to keep your reflexes sharp.

Sperm cells are swimming missiles designed for one purpose. The acrosome contains enzymes to break through the egg's defences, the middle section is packed with mitochondria for energy, and the tail provides propulsion. They're basically biological torpedoes.

Palisade cells in plant leaves are solar panel specialists, crammed full of chloroplasts to maximise photosynthesis. They're positioned at the top of leaves to catch the most sunlight possible.

Amazing Fact: A single sperm cell can swim up to 25 cm per hour - that might sound slow, but for something microscopic, it's incredibly fast!

9
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

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  • Access to all documents
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By signing up you accept Terms of Service and Privacy Policy

Plant Transport and Root Cells

Root hair cells are like tiny straws with massive surface area thanks to their finger-like projections. They're packed with mitochondria to power the active transport of mineral ions against concentration gradients - basically pumping nutrients uphill.

Xylem cells are nature's plumbing system. These dead, hollow tubes transport water and minerals from roots to leaves. Their walls are strengthened with lignin (the stuff that makes wood hard), creating sturdy pipes that can handle the pressure.

Phloem cells are the food delivery service, transporting sugars made during photosynthesis to wherever the plant needs energy. They're living cells with perforated end walls and minimal internal structures to maximise flow space.

Plant Engineering: Xylem and phloem together form vascular bundles - think of them as the plant's circulatory system, with xylem as arteries and phloem as veins!

10
of 10
1. A cells + microscopy

All organisms are made of cells:
Animals, plants and fungi are made of Eukaryotic cells.
-These have a nucleus"
Bac

Sign up to see the content. It's free!

  • Access to all documents
  • Improve your grades
  • Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Microscopy and Magnification

Magnification tells you how much bigger the image is compared to the real object - if something appears 10 times larger than actual size, it's magnified 10×. Resolution is about detail - it's the smallest distance between two points that can still be seen as separate.

Using a light microscope properly requires a systematic approach: start with low power to locate your specimen, then gradually increase magnification whilst fine-tuning the focus. Rushing to high power first usually means you'll lose your specimen entirely.

Total magnification is calculated by multiplying the eyepiece lens magnification by the objective lens magnification. If your eyepiece is 10× and your objective is 40×, your total magnification is 400×.

Practical Tip: Always start with the lowest power objective lens and work your way up - this prevents you from crashing the lens into your slide and gives you the best chance of finding interesting specimens!

We thought you’d never ask...

What is the Knowunity AI companion?

Our AI Companion is a student-focused AI tool that offers more than just answers. Built on millions of Knowunity resources, it provides relevant information, personalised study plans, quizzes, and content directly in the chat, adapting to your individual learning journey.

Where can I download the Knowunity app?

You can download the app from Google Play Store and Apple App Store.

Is Knowunity really free of charge?

That's right! Enjoy free access to study content, connect with fellow students, and get instant help – all at your fingertips.

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SociologySociology

Sociology of Families: Comprehensive Revision

Dive into an extensive overview of family dynamics, perspectives, and patterns in sociology. This resource covers key concepts such as family diversity, gender roles, marriage, and the impact of social policies on family structures. Perfect for A-Level Sociology students preparing for Paper 2.

1273,6782,307
CriminologyCriminology

Criminology: Crime & Punishment Overview

Comprehensive mindmaps covering key concepts in the Crime and Punishment topic for WJEC Criminology Unit 4. This resource includes detailed insights into the Criminal Justice System, crime prevention strategies, sentencing models, and the roles of various agencies. Ideal for A-Level revision, ensuring you grasp essential theories and legislative processes to excel in your exams.

1254,8731,059
SociologySociology

Comprehensive Crime & Deviance Overview

Explore an extensive revision of crime and deviance topics, including theories, types of crime, and the impact of media. This resource covers key concepts such as Marxism, functionalism, gender and crime, and the influence of globalization on criminal behavior. Ideal for students seeking a thorough understanding of criminology and its various theories. Type: Full Topic Revision.

1251,6571,399
C
BiologyBiology

Cell Biology and Cell structure

cell structures

93,2520
English LiteratureEnglish Literature

An Inspector Calls: Character Insights

Explore in-depth analysis and key quotes for characters in J.B. Priestley's 'An Inspector Calls'. This resource covers Gerald Croft, Inspector Goole, Sheila Birling, Mrs. Birling, Eric Birling, and Eva Smith, focusing on themes of class, gender roles, and social responsibility. Ideal for students aiming for Grade 8 and above.

1025,434907
CriminologyCriminology

WJEC Unit 4 Criminology

Criminology unit 4 detailed revision note

127,155125
CriminologyCriminology

Criminology Theories Overview

Explore key criminology theories and their implications on crime and deviance. This comprehensive summary covers biological, psychological, and sociological perspectives, including labelling theory, right realism, and the impact of social campaigns on policy development. Ideal for A-Level criminology students seeking to understand the complexities of criminal behaviour and the factors influencing crime prevention strategies.

129,761210
English LiteratureEnglish Literature

Romeo and Juliet: Key themes

Key Romeo and Juliet themes and analysed quotes

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