How to Make Amines from Haloalkanes, Amino Acids and More!

ziyah

20/03/2023

Chemistry

Amines, Amides and Amino Acids

Subjects

Chemistry

Organic chemistry

Amines (a-level only)

181

•

20 Mar 2023

•

2 pages

How to Make Amines from Haloalkanes, Amino Acids and More!

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ziyah

@ziy4h

Amines and Amino Acids: Structure, Properties, and Synthesis

Amines are... Show more

Amines
derived from ammonia molecules, contains nitrogen atom where hydrogens are replaced with an organic
group. Leg. alkyl group)
H
CH3
•P

Synthesis of Amines and Amino Acids

This page covers the synthesis methods for aliphatic and aromatic amines, as well as the structure and properties of amino acids.

Making Aliphatic Amines

There are two main methods for synthesizing aliphatic amines:

Reacting halogenoalkanes with excess ammonia

Example: The reaction of chloroethane with ammonia produces ethylamine (a primary amine) and ammonium chloride.

CH₃CH₂Cl + NH₃ → CH₃CH₂NH₂ + NH₄Cl

This method can produce a mixture of primary, secondary, and tertiary amines, as well as quaternary ammonium salts, due to further reactions of the initial product.

Reducing nitriles

Synthesis of Aromatic Amines

Aromatic amines, such as phenylamine, are typically made by reducing nitro compounds. This process involves two steps:

Heating nitrobenzene with concentrated HCl and tin under reflux to form a salt.
Reacting the salt with an alkali (e.g., NaOH) to produce the aromatic amine.

Highlight: Aromatic amines are important precursors in the production of dyes and pharmaceuticals.

Amino Acids

Amino acids are organic compounds containing both an amino group $-NH₂$ and a carboxylic acid group $-COOH$ .

Definition: Amino acids are amphoteric compounds with both acidic and basic properties due to their carboxyl and amino groups.

Key features of amino acids include:

General formula: RCH(NH₂)COOH
Chiral molecules (except glycine) due to four different groups around the central carbon atom
Ability to rotate plane-polarized light
Reactivity with acids and alkalis to form salts
Ability to form esters with alcohols

Vocabulary: Amphoteric substances can act as both acids and bases.

Amino acids play a crucial role in biological systems as the building blocks of proteins and have diverse applications in biochemistry and organic synthesis.

Types and Properties of Amines

Amines are organic compounds derived from ammonia, where hydrogen atoms are replaced by organic groups. They are classified based on the number of organic groups attached to the nitrogen atom.

Definition: Amines are nitrogen-containing compounds derived from ammonia, with one or more hydrogen atoms replaced by organic groups.

The three main types of amines are:

Primary amines: One organic group attached (e.g., methylamine)
Secondary amines: Two organic groups attached (e.g., dimethylamine)
Tertiary amines: Three organic groups attached (e.g., trimethylamine)

Example: Methylamine (CH₃NH₂) is a primary amine, while trimethylamine ((CH₃)₃N) is a tertiary amine.

Amines can also be classified as aliphatic or aromatic:

Aliphatic amines have non-aromatic organic groups attached to nitrogen.
Aromatic amines, like phenylamine (C₆H₅NH₂), have an aromatic ring attached to the nitrogen atom.

Highlight: The basicity of amines depends on the availability of the lone pair of electrons on the nitrogen atom. Factors affecting this include the type of groups attached to nitrogen and electron density.

Amines act as bases due to their ability to accept protons using their lone pair of electrons. They also function as nucleophiles, attacking electron-deficient carbon atoms in various reactions.

Vocabulary: A nucleophile is a chemical species that donates an electron pair to form a chemical bond.

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Subjects

Chemistry

Organic chemistry

Amines (a-level only)

Chemistry

•

181

•

20 Mar 2023

•

2 pages

How to Make Amines from Haloalkanes, Amino Acids and More!

ziyah

@ziy4h

Amines and Amino Acids: Structure, Properties, and Synthesis

Amines are nitrogen-containing organic compounds derived from ammonia. They play crucial roles in biological systems and chemical synthesis. This guide explores the types of amines, their properties, synthesis methods, and the related... Show more

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Synthesis of Amines and Amino Acids

This page covers the synthesis methods for aliphatic and aromatic amines, as well as the structure and properties of amino acids.

Making Aliphatic Amines

There are two main methods for synthesizing aliphatic amines:

Reacting halogenoalkanes with excess ammonia

Example: The reaction of chloroethane with ammonia produces ethylamine (a primary amine) and ammonium chloride.

CH₃CH₂Cl + NH₃ → CH₃CH₂NH₂ + NH₄Cl

This method can produce a mixture of primary, secondary, and tertiary amines, as well as quaternary ammonium salts, due to further reactions of the initial product.

Reducing nitriles

Synthesis of Aromatic Amines

Aromatic amines, such as phenylamine, are typically made by reducing nitro compounds. This process involves two steps:

Heating nitrobenzene with concentrated HCl and tin under reflux to form a salt.
Reacting the salt with an alkali (e.g., NaOH) to produce the aromatic amine.

Highlight: Aromatic amines are important precursors in the production of dyes and pharmaceuticals.

Amino Acids

Amino acids are organic compounds containing both an amino group $-NH₂$ and a carboxylic acid group $-COOH$ .

Definition: Amino acids are amphoteric compounds with both acidic and basic properties due to their carboxyl and amino groups.

Key features of amino acids include:

General formula: RCH(NH₂)COOH
Chiral molecules (except glycine) due to four different groups around the central carbon atom
Ability to rotate plane-polarized light
Reactivity with acids and alkalis to form salts
Ability to form esters with alcohols

Vocabulary: Amphoteric substances can act as both acids and bases.

Amino acids play a crucial role in biological systems as the building blocks of proteins and have diverse applications in biochemistry and organic synthesis.

Sign up to see the contentIt's free!

Access to all documents

Improve your grades

Join milions of students

By signing up you accept Terms of Service and Privacy Policy

Types and Properties of Amines

Amines are organic compounds derived from ammonia, where hydrogen atoms are replaced by organic groups. They are classified based on the number of organic groups attached to the nitrogen atom.

Definition: Amines are nitrogen-containing compounds derived from ammonia, with one or more hydrogen atoms replaced by organic groups.

The three main types of amines are:

Primary amines: One organic group attached (e.g., methylamine)
Secondary amines: Two organic groups attached (e.g., dimethylamine)
Tertiary amines: Three organic groups attached (e.g., trimethylamine)

Example: Methylamine (CH₃NH₂) is a primary amine, while trimethylamine ((CH₃)₃N) is a tertiary amine.

Amines can also be classified as aliphatic or aromatic:

Aliphatic amines have non-aromatic organic groups attached to nitrogen.
Aromatic amines, like phenylamine (C₆H₅NH₂), have an aromatic ring attached to the nitrogen atom.

Highlight: The basicity of amines depends on the availability of the lone pair of electrons on the nitrogen atom. Factors affecting this include the type of groups attached to nitrogen and electron density.

Amines act as bases due to their ability to accept protons using their lone pair of electrons. They also function as nucleophiles, attacking electron-deficient carbon atoms in various reactions.

Vocabulary: A nucleophile is a chemical species that donates an electron pair to form a chemical bond.

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Best app on earth! no words because it’s too good

Thomas R

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Basil

Android user

David K

iOS user

Sudenaz Ocak

Android user

In school I was really bad at maths but thanks to the app, I am doing better now. I am so grateful that you made the app.

Greenlight Bonnie

Android user

Rohan U

Android user

Xander S

iOS user

Elisha

iOS user

Paul T

iOS user

Stefan S

iOS user

Samantha Klich

Android user

Anna

iOS user

Best app on earth! no words because it’s too good

Thomas R

iOS user

Basil

Android user

David K

iOS user

Sudenaz Ocak

Android user

In school I was really bad at maths but thanks to the app, I am doing better now. I am so grateful that you made the app.

Greenlight Bonnie

Android user

Rohan U

Android user

Xander S

iOS user

Elisha

iOS user

Paul T

iOS user